|Other Titles||Endobronchial metastasis from prostate cancer: analysis of cases and review of the literatures|
|Abstract||目的 分析前列腺癌支气管黏膜转移的临床、影像、病理特征以及诊断和治疗方法 .方法 报告1例累及支气管黏膜的前列腺癌并结合文献报道的有病理证据确诊的9例患者的病例资料.对其临床、影像、病理特征以及诊断和治疗进行分析. 结果 支气管黏膜受累的晚期前列腺癌确诊时年龄偏大,平均65.5岁,多出现咯血(5/10)、咳嗽(4/10)、呼吸困难(4/10)和体质量下降(5/10),影像学表现为纵隔及肺门淋巴结增大(4/10)、肺门肿物(3/10)、肺不张(2/10)等,支气管镜下更多表现为单一叶或段分布(6/10),双肺上叶支气管更易受累(7/10),多数呈现息肉或肿块样腔内肿物(8/10),也可呈现为浸润性病变(2/10),均不同程度地导致管腔狭窄.免疫组化法检测前列腺特异抗原和(或)酸性磷酸酶阳性.多数患者对内分泌治疗反应良好. 结论 前列腺癌支气管黏膜转移在临床、影像特征上与支气管源性恶性肿瘤相似,免疫组化检测有助于鉴别诊断,内分泌治疗可取得显著的短期疗效.|
Objective To analyze the clinical, radiologic and pathological features of endobronchial metastasis from prostate cancer, and its diagnosis and treatment. Methods Ten cases of endobronchial metastasis from prostate cancer with pathological evidence in our hospital were retrospectively analyzed. The clinical, radiologie and pathological features and the diagnostic procedures and treatment of the cases were reported and analyzed while combined with literature. Results An average age at diagnosis of advanced prostate cancer was 65.5 years. Emoptysis(5/10), cough (4/10), dyspnea (4/10) and weight loss (5/10) were the common symptoms. Chest X-ray disclosed hilar and mediastinal lymphadenopathy (4/10), hilar mass (3/10) or atelectasis (2/10) . Bronchoscopic examination revealed that most of lesion located in single lobar or segmental bronchus (6/10). Bilateral upper lobe were most susceptibly involved(7/10). Polypoid lesions or mass in lumen of bronchi(8/10)were more frequent than infiltrative lesion(2/10), which could obstruct the orifice of the bronchi in different extent. Immunohistochemical staining for prostate specific antigen or prostatic acid phosphatase was positive, and most patients responded well to endocrine therapy. Conclusions Clin.ical and radiologic features of endobronchial metastasis from prostate cancer are similar to those of primary bronchogenic carcinoma. Immunohistoehemical study is helpful for differential diagnosis and the short-term efficacy of endocrine therapy is significant.
|Appears in Collections:||第一医院|