Title我国长寿地区90岁以上老人血浆超氧化物歧化酶和丙二醛含量及影响因素
Other TitlesLevel and effect factors of superoxide dismutase and malondialchehyche of the old people aged 90 and over in longevity regions, China
Authors殷召雪
施小明
徐建伟
翟屹
柳玉芝
曾毅
Affiliation中国疾病预防控制中心慢性病防治与社区卫生处,北京,102206
北京大学国家发展研究院中国经济研究中心
Keywords老年人
长寿
血浆
超氧化物歧化酶
丙二醛
Aged
Longevity
Plasma
Superoxide dismutase
Malondialchelyche
Issue Date2010
Publisher中华预防医学杂志
Citation中华预防医学杂志.2010,44,(2),123-127.
Abstract目的 分析我国长寿地区90岁以上老人血浆超氧化物歧化酶(SOD)和脂质过氧化产物丙二醛(MDA)含量,并探讨其影响因素.方法 选取河南夏邑县、湖北钟祥市、湖南麻阳县、广东佛山市三水区和广西永福县5个地区的所有百岁老人并编号,按照年龄尾数与编号尾数相同的原则,就近匹配选取同性别90~99岁高龄老人,共计496名.问卷调查民族、教育程度、膳食状况、吸烟、饮酒、饮茶和体力活动等情况.每人抽取4 ml静脉血,共采集到436份血样.测定甘油三酯(TG)、SOD、MDA、钙、镁和微量元素等相关指标.采用非条件logistic回归分析血浆SOD和MDA水平的影响因素.结果 90岁以上老人血浆SOD活力平均为(31.19±5.51)U/ml,MDA平均含量为(4.68±1.98)μmol/L.少数民族90岁以上老人血浆SOD活力为(27.55±4.97)U/ml,低于汉族[(31.73±5.39)U/ml;t=5.85,P<0.01];少数民族90岁以上老人血浆MDA含量为(5.58±1.95)μmol/L,高于汉族[(4.54±1.95)μmoL/L;t=-3.94,P<0.01].logistic回归分析结果表明,少数民族90岁以上老人血浆SOD活力低于汉族(OR=0.493,P<0.05);MDA含量则高于汉族(OR=5.412,P<0.05).除民族外,对血浆SOD活力影响有统计学意义的因素还包括肉类摄入频率、蛋类摄入频率、血浆硒含量(OR值分别为0.388、2.260和1.906,P值均<0.05);对血浆MDA含量影响有统计学意义的因素还包括奶类摄入频率、体力活动和TG(OR值分别为0.435、1.850和1.647,P值均<0.05).结论 我国长寿地区90岁以上老人血浆SOD水平较高,MDA水平较低.SOD水平的影响因素包括民族、蛋类摄入情况、肉类摄入情况和血浆硒的水平;影响MDA水平的因素有民族、奶类摄入情况、体力活动情况和血浆TG水平.
Objective To explore the level and effect factors of superoxide dismutase(SOD) and malondialchelyche (MDA) of the people aged 90 years old and above in longevity regions in China. Methods From Xiayi county (Henan province), Zhongxiang county (Hubei province), Mayang county (Hunan province), Foshan county Sanshui district (Guangdong province) and Yongfu county (Guangxi province), the people of hundred-year were selected and numbered. The old people aged 90 -99 according to the age and sex were appointed by the centenarians' code and 496 people were selected in total. Questionnaire investigation was conducted on nationality, education, nutrition, smoking, alcohol drinking, tea drinking and physical activities. 436 blood sampling (4 ml Per sampling) were conducted and the level of triglyceride (TG) ,SOD, MDA, Ca, Mg, and some microelements were determined. Non-conditional logistic regression analysis was conducted to explore the effect factors of SOD and MDA in plasma. Results Analysis showed that the activity of plasma SOD was (31.19 ± 5.51) U/ml, and the content of MDA was (4. 68±1.98) μmol/L. The SOD level of minority people of 90 years old and over was(27.55±4. 97) U/ml,lower than that of Han nationality ((31.73 ± 5.39) U/ml; t = 5. 85, P < 0. 01) ; the MDA level of minority people of 90 years old and over was (5. 58 ± 1.95) μmoL/L, higher than that of Han nationality ((4. 54 ± 1.95) μmol/L; t = -3.94, P < 0. 01). Logistic regression showed, comparing with the Han nationality, the minority had lower level of SOD (OR = 0. 493), and higher level of MDA (OR = 5.412, P < 0. 05). Beside nationality, the factors significantly affecting the activity of SOD included the intake frequency of meat, intake frequency of eggs and plasma concentration of Se (OR values were 0. 388,2. 260 and 1. 906, P < 0. 05). The factors significantly affecting the level of MDA included the intake frequency of milk,physical activity and the level of TG(OR values were 0.435,1.850 and 1.647,P<0.05). Conclusion The level of SOD of the oldest-old people aged 90 years old and over is relatively higher than the younger ones, and the level of MDA is relatively lower in longevity region, China. The effect factors of SOD are nationality, meat intake frequency, eggs intake frequency and the level of Se in plasma. The effect factors of MDA are nationality, milk intake frequency,physical activity and the level of TG in plasma.
URIhttp://hdl.handle.net/20.500.11897/288881
ISSN0253-9624
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