| Title | 肿瘤组织傅里叶变换红外光谱诊断方法的比较研究 |
| Other Titles | A Comparative Study of Malignant Tissue Diagnosis Using ATR and Microscopy FTIR Spectroscopy |
| Authors | 任予 徐怡庄 赵莹 杨丽敏 李庆波 张元福 翁诗甫 石景森 徐端夫 吴瑾光 |
| Affiliation | 北京大学化学与分子工程学院,稀土材料化学及应用国家重点实验室,北京,100871 西安交通大学第一医院,陕西,西安,710061 北京大学化学与分子工程学院,稀土材料化学及应用国家重点实验室,北京,100871 中国科学院化学研究所,北京,100080 西安交通大学第一医院,陕西,西安,710061 |
| Keywords | FTIR 显微红外法 衰减全反射法 肿瘤组织 FTIR infrared microscopy ATR tumor tissue |
| Issue Date | 2004 |
| Publisher | 光谱学与光谱分析 |
| Citation | 光谱学与光谱分析.2004,24,(8),930-932. |
| Abstract | 在前期的肿瘤组织红外光谱诊断方法研究中, 采用水平衰减全反射(ATR)红外光谱诊断法在多种肿瘤组织样品中取得了与病理诊断很好符合的实验结果; 针对文献报道中多采用的显微红外光谱法, 文章对同一肿瘤组织样品应用两种方法采集红外光谱, 比较测量条件及光谱诊断结果, 研究结果表明ATR法主要测量了整块组织的光谱信息, 避免了组织结构不均一, 微区采样扫描取点少对光谱诊断结果的影响, 获得的光谱可以为临床应用提供判断依据. A comparative FTIR study was undertaken between ATR (attenuated total reflection) and infrared microsoopy on their application to measuring the same tissue for cancer diagnosis. The measurements showed that the coincidence of pathological diagnosis with ATR is higher than that of microscopy FTIR method. The result indicated that the measured area of tumor tissue is critical. The area for microscopy measurement is similar to250 mum(2), it reflects the heterogeneity of the tissue. However, the ATR measurement provides more information of malignant tissue for the measured area is 1.9 x 10(5) times than microscopy. Therefore, ATR exhibit the high accuracy in cancer detection for clinical application. |
| URI | http://hdl.handle.net/20.500.11897/114125 |
| ISSN | 1000-0593 |
| DOI | 10.3321/j.issn:1000-0593.2004.08.009 |
| Indexed | SCI(E) PubMed 中文核心期刊要目总览(PKU) 中国科技核心期刊(ISTIC) 中国科学引文数据库(CSCD) |
| Appears in Collections: | 化学与分子工程学院 稀土材料化学与应用国家重点实验室 |
