小Y核型对男性不育影响的临床分析

Abstract

目的：探讨单纯小Y染色体核型对男性生育障碍的影响及其临床意义。方法：研究对象分为A组（男性不育）及B组（配偶既往不良妊娠史或羊水穿刺示胎儿染色体异常等），比较不同组别间小Y核型的检出率并分析其临床效应。结果：共检出30例小Y核型。其中A组12例，B组18例。两组间小Y核型的检出率没有显著差异（P＝0.971）。小Y核型的临床效应为：无精症、少精症、配偶胚胎停育、自然流产等不良妊娠结局。结论：小Y核型可能具备某些潜在的临床效应，可能会对男性生精过程及配偶的不良妊娠结局产生影响，需要在分子生物学及功能基因组学层面继续深入验证。

To investigate the effects of bit Y chromosome configuration on male fertility and to evaluate the relevant clinical significance.Methods:The relevant cases were divided into two groups,where A group included male infertile cases while B group included cases whose wife had adverse pregnancy history or the ab-normal amniotic fluid punctures.Cytogenetics of patients was examined by culturing peripheral-blood lymphocyte and G-banding technology,and karyotyping analysis technique was used to study the bit Y chromosome in two dif-ferent groups.Results:Among the 2139 cases,30 cases were found with abnormal karyotype of bit Y chromo-some.,including 12 ones in group A and 18 ones in group B,with no significant difference (P=0.971).The main clinical effects of bit Y were azoospermia,oligozoospermia,miscarriage,embryonic diapause and fetal anomalies,et al.Conclusion:The bit Y chromosomal abnormality may have some potential clinical effects which may affect the spermatogenesis and adverse pregnancy.Therefore,a detailed mechanism study needs to be further investigated.