Title长期持续气道正压通气对阻塞性睡眠呼吸暂停低通气综合征患者血压影响的荟萃分析
Other TitlesEffect of long-term continuous positive airway pressure ventilation on blood pressure in patients with obstructive sleep apnea hypopnea syndrome:a meta-analysis of clinical trials
Authors莫莉
何权瀛
Affiliation100044,北京大学人民医院呼吸内科
Keywords睡眠呼吸暂停,阻塞性
持续气道正压
动态血压监测
荟萃分析
Issue Date2007
Publisher中华医学杂志
Citation中华医学杂志.2007,87,(17),1177-1180.
Abstract目的 探讨长期持续气道正压(CPAP)通气能否降低阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血压水平.方法 用关键词途径从MEDLINE、中国期刊全文专题数据库计算机检索系统检索2000至2006年的相关文献,将观察对象限制为OSAHS患者,CPAP治疗≥4周,比较CPAP和非CPAP治疗对24h血压影响的所有临床随机对照研究数据进行荟萃分析.结果 7项研究共471例患者被纳入荟萃分析,其中3项研究支持CPAP可以降低OSAHS患者24 h平均舒张压;而另4项研究不支持.荟萃分析结果表明长期CPAP治疗可以降低OSAHS患者24 h平均舒张压加权均数差:-1.78(95% CI:-3.34,-0.22)].结论 长期CPAP治疗可以降低OSAHS患者24 h平均舒张压.
To explore whether long-term continuous positive airway pressure (CPAP) ventilation is effective to decrease the blood pressure in the patients with obstructive sleep apnea hypopnea syndrome (OSAHS) accompanied with hypertension.Literatures of relevant randomized, controlled, prospective, clinical trials 2000 - 2006 in English and Chinese were retrieved from Medline and CNKI based on the criteria: the subjects being patients with OSAHS, the study lasting at least 4 weeks, and the effect on 24 hours ambulatory blood pressure in CPAP group being compared with that in no-CPAP group. The data thus collected underwent meta-analysis.471 cases in 7 studies were included. Three of the 7 studies indicated that CPAP ventilation could decrease the diastolic blood pressure in the patients with OSAHS and four studies showed no significant difference in the effect of CPAP on blood pressure between the two groups. From meta-analysis, the weighted mean difference (WMD) in fixed effect model of 24 h diastolic blood pressure (DBP) was -1.78 [95% CI: -3.34, -0.22]; the WMD (fixed) of 24 h systolic blood pressure (SBP) was -0.95 [95% CI: -2.85, 0.94], and the WMD (random) of 24 h mean blood pressure (MBP) was -1.25 [95% CI: -4.00, 1.49].The long-term CPAP ventilation can decrease the 24 h DBP.
URIhttp://hdl.handle.net/20.500.11897/125126
ISSN0376-2491
DOI10.3760/j:issn:0376-2491.2007.17.007
IndexedPubMed
中文核心期刊要目总览(PKU)
中国科技核心期刊(ISTIC)
中国科学引文数据库(CSCD)
Appears in Collections:人民医院

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