TitleIs the Hypoglycemic Action of Vanadium Compounds Related to the Suppression of Feeding?
AuthorsHuang, Meiling
Wu, Yaling
Wang, Na
Wang, Ziwei
Zhao, Pan
Yang, Xiaoda
AffiliationPeking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China.
Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China.
Peking Univ, SATCM Key Lab Compound Drug Detoxificat, Beijing 100191, Peoples R China.
Keywordsbis((5-Hydroxy-4-oxo-4H-pyran-2-yl) methyl 2-hydroxy-benzoatato) oxovanadium (IV)
Vanadium
Diabetes
Feeding suppression
Peroxisome proliferator-activated receptor gamma
c-Jun N-terminal protein kinase
INSULIN-RECEPTOR SUBSTRATE-1
PPAR-GAMMA
DIABETES-MELLITUS
BLOOD-GLUCOSE
IN-VITRO
VANADATE
RESISTANCE
INHIBITION
PATHWAY
JNK
Issue Date2014
Publisher生物痕量元素研究
CitationBIOLOGICAL TRACE ELEMENT RESEARCH.2014,157,(3),242-248.
AbstractVanadium compounds exhibit effective hypoglycemic activity in both type I and type II diabetes mellitus. However, there was one argument that the hypoglycemic action of vanadium compounds could be attributable to the suppression of feeding-one common toxic aspect of vanadium compounds. To clarify this question, we investigated in this work the effect of a vanadyl complex, BSOV (bis((5-hydroxy-4-oxo-4H-pyran-2-yl)methyl-2-hydroxy-benzoatato) oxovanadium (IV)), on diabetic obese (db/db) mice at a low dose (0.05 mmol/kg/day) when BSOV did not inhibit feeding. The experimental results showed that this dose of BSOV effectively normalized the blood glucose level in diabetic mice without affecting the body weight growth. Western blotting assays on the white adipose tissue of db/db mice further indicated that BSOV treatment significantly improved expression of peroxisome proliferator-activated receptor gamma (PPAR gamma) and activated AMP-activated protein kinase (AMPK). In addition, vanadium treatment caused a significant suppression of phosphorylation of c-Jun N-terminal protein kinase (JNK), which plays a key role in insulin-resistance in type II diabetes. This is the first evidence that the mechanism of insulin enhancement action involves interaction of vanadium compounds with JNK. Overall, the present work indicated that vanadium compounds exhibit antidiabetic effects irrelevant to food intake suppression but by modulating the signal transductions of diabetes and other metabolic disorders.
URIhttp://hdl.handle.net/20.500.11897/156456
ISSN0163-4984
DOI10.1007/s12011-013-9882-6
IndexedSCI(E)
CPCI-S(ISTP)
PubMed
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天然药物与仿生药物国家重点实验室

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