Title天津市2010-2012年社区人群百日咳血清流行病学调查
Other TitlesA sero-epidemiological study on pertussis among the community-based populations in Tianjin during 2010-2012
Authors黄海涛
刘勇
高志刚
刘鹏
李永成
张颖
曹卫华
Affiliation30001天津市疾病预防控制中心
北京大学公共卫生学院
300011,天津市疾病预防控制中心
北京大学公共卫生学院
Keywords百日咳毒素抗体 血清流行病学 估计发病率 Antibody to pertussis toxin immunoglobulin Sero-epidemiology Estimated incidence rate
Issue Date2014
Publisher中华流行病学杂志
Citation中华流行病学杂志.2014,35,(12),1354-1357.
Abstract目的 研究天津市社区人群中百日咳血清流行病学水平.方法 应用ELISA对2010-2012年天津市社区人群单份血百日咳毒素IgG(PT-IgG)抗体进行检测,分析抗体水平与百日咳发病率之间的关系.结果 1 825人的PT-IgG抗体平均阳性率为10.96%,其中0~3岁组最高,为24.37% ~ 13.61%(P<0.001).4~ 83岁年龄组阳性率为8.84%,估计发病率为10 852/10万,其中51 ~ 83岁组估计发病率最高,为18 986/10万(P=0.001),且随着年龄的增长呈线性升高趋势(r=0.976,P<0.001).3年间抗体阳性率的差异有统计学意义(P=0.001),与当年报告发病率之间呈线性相关(r=0.992,P<0.001).3个监测地区间抗体阳性率的差异有统计学意义(P=0.034),与该监测地区年均报告发病率呈线性关系(r=0.996,P<0.001).结论 天津市百日咳发病的流行病学趋势和人群感染的血清流行病学趋势一致.
To study the sero-epidemiology of pertussis immunity and related factors among the community-based populations in Tianjin.Antibodies to pertussis toxin immunoglobulin and IgG (PT-IgG) levels among the community-based populations were examined, using ELISA over the three consecutive years. Subjects that were older than 4 years of age, with concentration of anti-PT-IgG higher than 40 IU/ml were recognized as having recent Bordetella (B.) pertussis infection.Of the 1 825 study subjects, the average positive rate of anti-PT-IgG was 10.96% . The highest rate appeared as 24.37%-13.61% among the 0-3 year-olds (P < 0.001). The positive rate was 8.84%, and the estimated incidence of recent infection became 10 852 per 100 000 among those age 4-83 year-olds. Peak of the estimated incidence rate of recent infection was 18 986 per 100 000 in the age group of 51-83 year-olds (P = 0.001), but increasing linearly along with the increase of age (r = 0.976, P < 0.001). There were statistically significant differences seen in the antibody positive rate of 3-year period of study (P = 0.001), and appeared linear correlation with the reported annual incidence (r = 0.992, P < 0.001). There were statistically significant differences in the antibody positive rates of the 3 monitoring areas(P = 0.034), also showing a linear correlation with the reported annual incidence (r = 0.996, P < 0.001).Results from this study indicated that B. pertussis infection had been common, particularly in adults living in the communities in Tianjin, calling for the current pertussis immunization strategy to be improved in order to control the pertussis reemerge in China.
URIhttp://hdl.handle.net/20.500.11897/188373
ISSN0254-6450
DOI10.3760/cma.j.issn.0254-6450.2014.12.009
IndexedPubMed
中文核心期刊要目总览(PKU)
中国科技核心期刊(ISTIC)
中国科学引文数据库(CSCD)
Appears in Collections:公共卫生学院

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