TitleTricholemmal carcinoma of the head and neck region: A report of 15 cases
AuthorsFeng, Zhien
Zhu, Han-Guang
Wang, Li Zhen
Zheng, Jia-Wei
Chen, Wan-Tao
Zhang, Zhiyuan
Dong, Wei
Qu, Weiguo
Wang, Yan An
AffiliationPeking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China.
Shanghai Jiao Tong Univ, Peoples Hosp 9, Sch Med, Dept Oral & Maxillofacial Head & Neck Oncol, Shanghai 200011, Peoples R China.
Shanghai Jiao Tong Univ, Peoples Hosp 9, Sch Med, Dept Oral Pathol, Shanghai 200011, Peoples R China.
Dalian Univ, Dalian Stomatol Hosp, Dept Oral & Maxillofacial Surg, Dalian 116021, Peoples R China.
Shanghai Jiao Tong Univ, Peoples Hosp 9, Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
Keywordstricholemmal carcinoma
clinicopathological features
head and neck
Issue Date2014
Publisheroncology letters
CitationONCOLOGY LETTERS.2014,7,(2),423-426.
AbstractTricholemmal carcinoma is an extremely rare malignancy of the skin, and its biological behavior and management is controversial. The objective of the present study was to investigate the clinicopathological characteristics and management of tricholemmal carcinoma of the head and neck region. The study analyzed 15 patients with tricholemmal carcinoma. Demographic and clinical data were collected, and features associated with the management and prognosis of tricholemmal carcinoma were analyzed. Two of the 15 patients were lost to follow-up. The results showed that, during the follow-up period, 5 of the 13 available patients succumbed to the causes of recurrence (n=3), neck lymph node metastasis (n=1) and Parkinson's disease (n=1). No patients developed distant metastasis. The disease-free survival (DFS) and overall survival (OS) were 31.1 +/- 7.8 and 32.9 +/- 7.4 months (mean +/- SE), respectively, and the DFS and OS rates were 69.2 and 61.5%, respectively. In conclusion, the biological behavior of tricholemmal carcinoma is locoregionally aggressive. The recommended management for head and neck tricholemmal carcinoma is radical resection and neck dissection, and post-operative radiotherapy may be considered for high-risk patients.
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