TitleCCAAT增强子结合蛋白β在胃癌中的表达及其临床意义
Other TitlesExpression of CCAAT/enhancer binding protein beta in human gastric carcinoma and its clinical significance
Authors杜云霞
张连海
王晓红
邢晓芳
程晓静
杜红
胡颖
李瑛爱
朱昱冰
Affiliation100142,北京大学肿瘤医院暨北京市肿瘤防治研究所胃肠肿瘤外科恶性肿瘤发病机制及转化研究教育部重点实验室
Keywords胃肿瘤 CCAAT增强子结合蛋白 高表达 预后 Stomach neoplasms CCAAT enhancer binding protein beta Overexpression Prognosis
Issue Date2013
Publisher中华胃肠外科杂志
Citation中华胃肠外科杂志.2013,16,(2),179-182.
Abstract目的 探讨CCAAT增强子结合蛋白β(CEBPB)在胃癌组织中的表达及其与胃癌临床病理参数及预后的关系.方法 用免疫组织化学染色方法对81例胃癌组织及其配对癌旁黏膜组织中CEBPB蛋白的表达进行检测,并分析其表达与胃癌临床病理特征及预后的关系.结果 CEBPB蛋白主要定位于细胞核,在胃癌组织中表达阳性率为16%(13/81),癌旁组织中无表达或弱表达.单因素分析显示,CEBPB阳性表达与胃癌远处转移有关(P=0.048).CEBPB阳性表达患者中位生存期19.4个月,低于CEBPB阴性表达患者的45.2个月(P=0.024).多因素分析显示,CEBPB阳性表达是影响本组胃癌患者的独立预后因素(HR=2.544,95%CI:1.154~5.610,P=0.021).结论 CEBPB在胃癌组织中表达增高提示预后不良.
To explore the expression of CCAAT/enhancer binding protein beta (CEBPB) in gastric carcinoma tissues and its association with clinicopathological features and prognosis.CEBPB protein expression level was detected by immunohistochemistry method in resected gastric carcinomas and adjacent gastric mucosa tissues (n=81), and its association with clinicopathological features and prognosis was analyzed.The immunohistochemical staining of CEBPB was predominantly in the nucleus with some cytoplasmic staining. As a result, 16% (13/81) of the gastric carcinomas were stained positively, whereas there was hardly positive expression in adjacent gastric mucosa tissues. There was a significant association between the expression of CEBPB and distant metastasis on univariate analysis (P<0.05). The median survival time in patients with positive CEBPB expression was significantly lower than those with negative CEBPB expression (19.4 months vs. 45.2 months, P=0.024). Multivariable analysis showed that CEBPB was independently associated with prognosis (HR=2.544, 95%CI:1.154-5.610, P=0.021).Up-regulation of CEBPB suggests poor prognosis in patients with gastric cancer.
URIhttp://hdl.handle.net/20.500.11897/190661
ISSN1671-0274
DOI10.3760/cma.j.issn.1671-0274.2013.02.024
IndexedPubMed
中国科技核心期刊(ISTIC)
中国科学引文数据库(CSCD)
Appears in Collections:北京肿瘤医院

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