TitleAnalysis of copy number variations of BS69 in multiple types of hematological malignancies
AuthorsYang, Hong
Zhang, Chao
Zhao, Xiaosu
Wu, Qi
Fu, Xinrong
Yu, Bo
Shao, Yong
Guan, Ming
Zhang, Wei
Wan, Jun
Huang, Xiaojun
AffiliationPeking Univ, Dept Hematol, Peoples Hosp, Inst Hematol, Beijing 100871, Peoples R China.
Peking Univ, Shenzhen Hosp, Dept Clin Lab, Shenzhen, Guangdong, Peoples R China.
Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen, Guangdong, Peoples R China.
Hong Kong Univ Sci & Technol, Dept Biochem, Hong Kong, Hong Kong, Peoples R China.
Fudan Univ, Dept Lab Med, Cent Lab, Huashan Hosp, Shanghai 200433, Peoples R China.
Ji Nan Univ, JNU HKUST Joint Lab, Guangzhou, Guangdong, Peoples R China.
Shenzhen PKU HKUST Med Ctr, Shenzhen 518036, Guangdong, Peoples R China.
KeywordsCopy number variations (CNVs)
BS69
Hematological malignancies
Acute myelogenous leukemia (AML)
Acute lymphoblastic leukemia (ALL)
Myelodysplastic syndrome (MDS)
ADENOVIRUS E1A-ASSOCIATED PROTEIN
ACUTE LYMPHOBLASTIC-LEUKEMIA
CHRONIC LYMPHOCYTIC-LEUKEMIA
HUMAN GENOME
GENE-EXPRESSION
STRUCTURAL VARIATION
CANCER
DELETION
PATHWAY
DNA
Issue Date2010
Publisherannals of hematology
CitationANNALS OF HEMATOLOGY.2010,89,(10),959-964.
AbstractBS69 was originally identified as an adenovirus E1A-binding protein and was found to be involved in multiple cellular events. A recent array-based study implicated the presence of copy number variations (CNVs) of BS69 in the genomes of acute myelogenous leukemia. CNVs are present in the general population at varying degrees and have been found to associate with various types of diseases including hematological malignancies. However, most of the current studies focused on the genome-wide screening of CNVs, and the functional impact of such regions needs to be extensively investigated in large amount of clinical samples. Thus, in our study, we collected 617 bone marrow samples from multi-types of hematological malignancies as well as healthy controls. We found significant association between the CNVs of BS69 and these hematological malignancies including acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), multiple myeloma (MM), and myelodysplastic syndrome (MDS). We also examined the expression of BS69 mRNA in the samples with one or two copies of DNA, and observed a weak yet positive correlation between the relative expression level and gene dosage. In general, the CNVs of BS69 have the potential to serve as a diagnostic indicator, alone or in combination with other markers, for hematological malignancies.
URIhttp://hdl.handle.net/20.500.11897/196146
ISSN0939-5555
DOI10.1007/s00277-010-0966-5
IndexedSCI(E)
PubMed
Appears in Collections:人民医院
深圳医院

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