北京地区卵巢恶性肿瘤发病相关因素分析

Abstract

目的:了解近年北京地区卵巢恶性肿瘤及其组织类型的相关因素,为预防提供依据.方法:对北京市18区(县)302例经手术病理确诊的卵巢恶性肿瘤患者和906例按年龄和地区匹配的健康对照进行问卷调查.结果:北京地区卵巢恶性肿瘤平均发病年龄51.63±14.44岁.多因素分析显示一、二级血亲卵巢癌家族史,不孕症,月经初潮年龄早(<13岁)和未采用避孕措施为卵巢恶性肿瘤的危险因素.浆液性卵巢癌的危险因素为一、二级血亲患卵巢癌家族史,累计哺乳时间短;黏液性卵巢癌的危险因素为未生育、糖尿病史、使用激素替代;其他卵巢恶性肿瘤的危险因素为未生育,一、二级血亲卵巢癌家族史,不孕症.结论:卵巢恶性肿瘤与遗传、排卵次数、生活方式等多因素相关,不同组织类型卵巢恶性肿瘤具有不同的相关因素.对于卵巢恶性肿瘤的高危人群,应加强监测,提高早期卵巢恶性肿瘤的检出,积极采取相应的预防措施,将有助于降低卵巢恶性肿瘤的死亡率.

Objective:To investigate the correlation factors of ovarian malignant tumor and its histological type in Beijing area to provide evidence for protection. Methods:A 1:3 case-control study was conducted in Beijing area. 302 cases with ovarian malignant tumor by pathological diagnoses and 906 healthy controls which were matched with age and area were interviewed by questionnaire in 18 district or county. Results: The average age of ovarian malignant tumor onset was 51.63 ±14.44. Multivariate logistic analysis showed that family history of ovarian malignant tumor, infertility, no contraception and early age of menarche( <13) were the risk factors of ovarian malignant tumor. For serous ovarian cancer, family history of ovarian malignant tumor and short accumulated lactation time were the risk factors. For mutinous ovarian cancer, nulliparity, diabetes and hormone replace treatment (HRT) were the risk factors. For the other histological type of ovarian malignant tumor. Nulliparity, family history of ovarian malignant tumor and infertility were the risk factors for the other histological types. Conclusions:Ovarian malignant tumor has relationship with multi-factors, especially with family history of ovarian malignant tumor, ovulation and life style. Different histological types of ovarian malignant tumor have different correlation factors. Women with family history of ovarian malignant tumor, infertility, no contraception and early age of menarche (<13) are the risk group of ovarian malignant tumor. Closing supervision of risk group would be helpful to find ovarian malignant tumor at early stage and actively take precaution to decrease the mortality.