TitleAssociation of surrogate and direct measures of adiposity with risk of metabolic syndrome in rural Chinese women
AuthorsOuyang, Fengxiu
Necheles, Jonathan
Wang, Binyan
Ma, Wei
Li, Zhiping
Liu, Xue
Tang, Genfu
Xing, Houxun
Xu, Xiping
Venners, Scott A.
Brickman, Wendy J.
Christoffel, Katherine Kaufer
Zimmerman, Donald
Wang, Xiaobin
AffiliationNorthwestern Univ, Feinberg Sch Med, Dept Pediat, Mary Ann & J Milburn Smith Child Hlth Res Program, Chicago, IL 60614 USA.
Childrens Mem Hosp, Chicago, IL 60614 USA.
Childrens Mem Res Ctr, Chicago, IL 60614 USA.
Northwestern Univ, Feinberg Sch Med, Div Gen Acad Pediat, Chicago, IL 60614 USA.
Beijing Univ, Affiliated Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China.
Anhui Med Univ, Inst Biomed, Hefei, Peoples R China.
Univ Illinois, Sch Publ Hlth, Ctr Populat Genet, Chicago, IL USA.
Northwestern Univ, Feinberg Sch Med, Dept Pediat, Div Endocrinol, Chicago, IL 60614 USA.
Northwestern Univ, Feinberg Sch Med, Dept Pediat, Mary Ann & J Milburn Smith Child Hlth Res Program, Box 157,2300 Childrens Plaza, Chicago, IL 60614 USA.
KeywordsBody mass index
Waist circumference
Body composition
Metabolic syndrome
Chinese women
Twins
BODY-MASS INDEX
INTERNATIONAL-DIABETES-FEDERATION
CARDIOVASCULAR RISK
BLOOD-PRESSURE
WAIST CIRCUMFERENCE
INSULIN-RESISTANCE
VISCERAL FAT
YOUNG-ADULTS
PREVALENCE
OBESITY
Issue Date2009
Publishereuropean journal of nutrition
CitationEUROPEAN JOURNAL OF NUTRITION.2009,48,(6),323-332.
AbstractMost studies linking obesity and metabolic syndrome (MS) have used body mass index (BMI) and waist circumference (WC) to measure obesity. While BMI is correlated with direct measures of total and central adiposity, it is influenced by lean body and bone mass. We hypothesize that direct measures of adiposity may help develop further insight into the link between obesity and MS, thus more accurately identifying individuals at high risk for MS. We examined how surrogate and direct measures of adiposity were associated with MS risk and if direct adiposity measures enhanced BMI and WC identification of MS risk. 3,734 Chinese female twins aged 20-39 years were studied. Percent body fat (%BF) and proportion of trunk fat to total BF (%TF) were assessed by DEXA. Graphic plots and generalized estimating equations were used to examine the associations of adiposity measures with MS and its components. Concordance of adiposity measures and MS abnormalities between monozygotic (MZ) and dizygotic (DZ) twin pairs were compared. The prevalence of MS increased for high BMI (a parts per thousand yen23 kg/m(2)), %BF (a parts per thousand yen32), WC (a parts per thousand yen80 cm), and (to a lesser degree) %TF (a parts per thousand yen50). Below those thresholds, the prevalence of MS was low (0-5.3%). %TF was independently associated with higher risk of MS and its components even after adjusting for BMI and WC. As a result, among women with normal BMI and WC, high %TF was associated with 1.3-2.0-fold elevated risk of MS components. In contrast, women with high BMI but normal WC and %TF neither have significantly increased risk of MS, nor for any component other than high BP. MZ twins showed higher concordance for MS and its components than DZ twins. In this lean Chinese rural female sample, BMI a parts per thousand yen 23 and WC a parts per thousand yen 80 were associated with a markedly increased risk of MS, which was further enhanced by elevated %TF. Even in women with a normal BMI and WC, %TF was independently associated with MS and its components. Twin analysis findings suggest that adiposity measurements and MS risk are influenced by genetics.
URIhttp://hdl.handle.net/20.500.11897/257552
ISSN1436-6207
DOI10.1007/s00394-009-0016-z
IndexedSCI(E)
Appears in Collections:第一医院

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