Title基于聚酰亚胺的神经微电极的制备及特性研究
Other TitlesThe fabrication and characteristic analysis of polyimide-based neural microelectrodes
Authors李晓倩
裴为华
归强
郭凯
王宇
王凯
汤戎昱
陈弘达
Affiliation中国科学院半导体研究所集成光电子学国家重点实验室 北京100083
中国科学院半导体研究所集成光电子学国家重点实验室 北京100083
兰州大学物理科学与技术学院 兰州730000
北京大学人民医院 北京100044
Keywords神经刺激电极 非光敏型聚酰亚胺 柔性 生物相容性 老化特性 电学特性
Issue Date2011
Publisher高技术通讯
Citation高技术通讯.2011,21,(12),1323-1328.
Abstract提出了一种基于非光敏型聚酰亚胺PI-5J的柔性薄膜神经微电极的制作方法,利用常规光刻技术设计和制作出了适合植入的柔性神经刺激微电极阵列,并通过离体实验对其进行了微电极的老化测试和电学特性测试,通过在体实验进行了微电极的生物相容性测试.测试结果显示,制作出的微电极不容易老化,而且具有很好的生物相容性和电学性能,此实验结果为进一步的动物在体实验提供了重要依据.上述制作柔性神经微电极的方法对于促进神经科学的基础研究和神经疾病的治疗和康复具有重要意义.
A method of fabricating flexible neural microelectrodes based on non-photosensitive polyimide PI-5J was proposed, and a novel flexible neural stimulating microelectrode array was designed and fabricated by the traditional photolithography process for animal implantation. The degeneration and electrical characteristics of this fabricated microelectrode array were tested in vitro. Its biocompatibility was tested in vivo. The results show the array's good degeneration-resistance, good biocompatibility and good electrical characteristics, which are the bases for its next stage tests in vivo. The fabrication method of the flexible microelectrode array proposed in the paper will promote the basic research on neural science, and the treatment, the rehabilitation of neural diseases.
URIhttp://hdl.handle.net/20.500.11897/262944
ISSN1002-0470
DOI10.3772/j.issn.1002-0470.2011.12.017
IndexedEI
中文核心期刊要目总览(PKU)
中国科技核心期刊(ISTIC)
中国科学引文数据库(CSCD)
Appears in Collections:人民医院

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