TitleS100 A14在子宫内膜癌中的表达及其意义
Other TitlesExpression and significance of S100A14 protein in endometrial adenocarcinomas
Authors侯文萍
钱景锋
井超
王翔宇
贺欢
刘芝华
崔竹梅
Affiliation青岛大学附属医院妇产科,青岛,266101
北京大学人民医院妇产科,北京,100191
中国医学科学院肿瘤研究所,北京,100021
Keywords子宫内膜癌
S100A14
免疫组化
Endometrialadenocarcinomas
S100A14
Immunohistochemistry
Issue Date2014
Publisher现代妇产科进展
Citation现代妇产科进展.2014,(9),677-680.
Abstract目的:探讨S100 A14在子宫内膜样腺癌中的表达及其临床意义。方法:采用免疫组化法检测子宫内膜癌组织、不典型增生子宫内膜组织、单纯性增生子宫内膜组织及正常子宫内膜组织中S100 A14的表达情况。结果:84例子宫内膜癌患者中,高、中分化与低分化癌组织中S100 A14表达具有统计学差异( P=0.020, P=0.034);行淋巴结清扫的74例子宫内膜癌患者中,淋巴结阴性与淋巴结阳性癌组织中S100 A14表达有统计学差异( P=0.044)。子宫内膜癌组织中S100 A14的表达与正常内膜组织比较,差异有统计学意义( P=0.034),单纯性增生、不典型增生子宫内膜组织中S100 A14的表达与正常内膜组织比较,无统计学差异。结论:S100 A14的表达下调与子宫内膜样腺癌的恶性程度及肿瘤转移程度相关。
Objective:To investigate the clinical significance of S100 A14 in endometri-al adenocarcinomas. Method:The expression of S100A14 was examined by immunohistochemis-try analysis in tissue microarrays which contains four kinds of tissues:endometrial carcinoma,a-typical endometrial tissues,hyperplasia endometrial tissues and normal endometrial tissues. Re-sult:The expression of S100 A14 in endometrial carcinoma tissues was significantly less than that in normal endometrial tissues(P=0. 034). Among 85 endometrial carcinoma patients, S100 A14 expression was significantly different between well differentiated and poorly differenti-ated patients(P=0. 020). The expression of S100A14 in moderately differentiated endometrial cancers was significantly higher than that in low differentiated endometrial cancers ( P =0. 034 ) . There were 74 patients who went on extrafascial hysterectomy or extensive hysterecto-my plus bilateral salpingo-oophorectomy and pelvic lymphadenectomy. S100A14 was significant-ly less in tissues with lymph node metastasis than those without lymph node metastasis( P=0. 044 ) . Conclusion:Decreased expression of S100 A14 is correlated with higher metastatic poten-tial and more poorly differentiated degree in human endometrial adenocarcinomas.
URIhttp://hdl.handle.net/20.500.11897/268803
ISSN1004-7379
DOI10.13283/j.cnki.xdfckjz.2014.09.005
Indexed中国科技核心期刊(ISTIC)
中国科学引文数据库(CSCD)
Appears in Collections:人民医院

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