Title那格列奈临床应用中国专家共识
Other TitlesClinical application of nateglinide:a Chinese expert consensus
Authors宁光
陈璐璐
陈名道
冯凭
高妍
郭晓蕙
李延兵
陆菊明
潘长玉
田浩明
王卫庆
薛耀明
严励
曾龙驿
朱大龙
邹大进
Affiliation上海市内分泌代谢病临床医学中心,上海市内分泌代谢病研究所,上海交通大学医学院附属瑞金医院内分泌代谢病科,200025
华中科技大学同济医学院附属协和医院内分泌科
天津医科大学总医院内分泌科
北京大学第一医院内分泌科
中山医科大学附属第一医院内分泌科
解放军总医院内分泌科
四川大学华西医院内分泌科
南方医科大学附属南方医院内分泌科
中山大学附属第二医院内分泌科
中山大学附属第三医院
南京大学医学院附属鼓楼医院内分泌科
第二军医大学长海医院内分泌科
Keywords那格列奈
中国专家共识
糖尿病,2型
Nateglinide
Chinese expert concensus
Diabetes mellitus,type 2
Issue Date2011
Publisher中华内分泌代谢杂志
Citation中华内分泌代谢杂志.2011,27,(5),后插1-后插3.
Abstract胰岛素早时相分泌缺陷是导致餐后血糖升高的重要原因.那格列奈是一种速效胰岛素促泌剂,可通过恢复2型糖尿病患者胰岛素早时相分泌以降低餐后血糖.其有效性和安全性得到了充分验证,对2型糖尿病的临床应用也日益广泛.2010年中国2型糖尿病治疗指南将磺脲类与格列奈类统称为胰岛素促泌剂,均作为备选的一线药物.AACE/ACE的共识声明中指出,格列奈类已成为二甲双胍之后的重要选择之一.为了进一步指导那格列奈临床应用,国内16位知名内分泌代谢专家经过认真讨论,拟写了此共识.本共识结合国内外证据,对那格列奈的研究结果进行了系统回顾与总结,对如何临床合理有效应用那格列奈提出指导性建议,供临床医师参考.
Impaired eady phase insulin secretion is an important reason for leading to postprandial hyperglycemia.Nateglinide is a rapid-acting insulin secretagogue,which reduces postprandial blood glucose of type 2diabetic patient by restoring early phase insulin secretion.The efficacy and safety have been fully verified by clinical administration and it is more widely used to treat type 2 diabetic patients.Both sulfonylureas and glinides were named insulin secretagogue agents and regarded as alternative first-line drugs in the 2010 Chinese Guideline for treatment of type 2 diabetes.AACE/ACE Consensus statement claimed that glinides would be one of the important choices after metformin.In order to further guide the clinical application of nateglinide,16 national specialists in the field of endocrinology and metabolism of China discussed,drafted,and edited this consensus.The current consensus combined clinical evidences at home and abroad.systematically reviewed and summarized tlle results of these studies about nateglinide.It will provide guiding recommendations and reference concerning how to reasonably and effectively use nateglinide in the clinical practice.
URIhttp://hdl.handle.net/20.500.11897/286893
ISSN1000-6699
DOI10.3760/cma.j.issn.1000-6699.2011.05.029
Indexed中文核心期刊要目总览(PKU)
中国科技核心期刊(ISTIC)
中国科学引文数据库(CSCD)
Appears in Collections:第一医院

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