TitleSimultaneous occurrence of hepatitis C virus-associated glomerulonephritis and AL amyloidosis
AuthorsCao, Yali
Zhang, Youkang
Wang, Suxia
Zhao, Minghui
Zou, Wanzhong
AffiliationPeking Univ, Div Renal, Dept Med,Hosp 1, Key Lab Renal Dis,Minist Hlth China,Inst Nephrol, Beijing 100034, Peoples R China.
KeywordsAL amyloidosis
glomerulonephritis
hepatitis C virus
KIDNEY
INFECTION
DISEASE
Issue Date2009
Publishernephrology dialysis transplantation
CitationNEPHROLOGY DIALYSIS TRANSPLANTATION.2009,24,(9),2943-2945.
AbstractWe report a 65-year-old male with hepatitis C virus (HCV)-associated glomerulonephritis (GN) and AL amyloidosis. This patient had a 14-year history of HCV infection with positive serum HCV RNA at presentation. Diagnosis of HCV-related GN was established using immunohistochemistry in which the HCV-NS3 antigen was mainly detected as granular deposition in glomerular mesangium. AL amyloidosis was determined by electron microscopy, positive Congo red staining and identification of lambda-chain in the kidney specimen and monoclonal IgG-lambda in serum and urine. Under immunoelectron microscopy, the HCV-NS3 antigen was found in electron-dense deposits, while lambda-chains appeared in the amyloid-like filaments.
URIhttp://hdl.handle.net/20.500.11897/304626
ISSN0931-0509
DOI10.1093/ndt/gfp296
IndexedSCI(E)
PubMed
Appears in Collections:第一医院

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