TitleLocal administration of icariin contributes to peripheral nerve regeneration and functional recovery
AuthorsChen, Bo
Niu, Su-ping
Wang, Zhi-yong
Wang, Zhen-wei
Deng, Jiu-xu
Zhang, Pei-xun
Yin, Xiao-feng
Han, Na
Kou, Yu-hui
Jiang, Bao-guo
AffiliationPeking Univ, Peoples Hosp, Dept Trauma & Orthoped, Beijing 100871, Peoples R China.
Capital Med Univ, Beijing Shijitan Hosp, Beijing, Peoples R China.
Peking Univ, Hlth Sci Ctr, Beijing 100871, Peoples R China.
Keywordsnerve regeneration
peripheral nerve
sciatic nerve
traditional Chinese medicine
icariin
sleeve bridging suture
nerve growth factor
NSFC grants
neural regeneration
SMALL-GAP TUBULIZATION
GROWTH-FACTOR
NEUROTROPHIC FACTOR
SUSTAINED-RELEASE
MICROSPHERES
REPAIR
INJURY
RATS
Issue Date2015
Publisherneural regeneration research
CitationNEURAL REGENERATION RESEARCH.2015,10,(1),84-89.
AbstractOur previous study showed that systemic administration of the traditional Chinese medicine Epimedium extract promotes peripheral nerve regeneration. Here, we sought to explore the therapeutic effects of local administration of icariin, a major component of Epimedium extract, on peripheral nerve regeneration. A poly(lactic-co-glycolic acid) biological conduit sleeve was used to bridge a 5 mm right sciatic nerve defect in rats, and physiological saline, nerve growth factor, icariin suspension, or nerve growth factor-releasing microsphere suspension was injected into the defect. Twelve weeks later, sciatic nerve conduction velocity and the number of myelinated fibers were notably greater in the rats treated with icariin suspension or nerve growth factor-releasing microspheres than those that had received nerve growth factor or physiological saline. The effects of icariin suspension were similar to those of nerve growth factor-releasing microspheres. These data suggest that icariin acts as a nerve growth factor-releasing agent, and indicate that local application of icariin after spinal injury can promote peripheral nerve regeneration.
URIhttp://hdl.handle.net/20.500.11897/306873
ISSN1673-5374
DOI10.4103/1673-5374.150711
IndexedSCI(E)
PubMed
中国科技核心期刊(ISTIC)
中国科学引文数据库(CSCD)
Appears in Collections:人民医院

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