TitleAssociation between Family History Risk Categories and Prevalence of Diabetes in Chinese Population
AuthorsZhang, Jinping
Yang, Zhaojun
Xiao, Jianzhong
Xing, Xiaoyan
Lu, Juming
Weng, Jianping
Jia, Weiping
Ji, Linong
Shan, Zhongyan
Liu, Jie
Tian, Haoming
Ji, Qiuhe
Zhu, Dalong
Ge, Jiapu
Chen, Li
Guo, Xiaohui
Zhao, Zhigang
Li, Qiang
Zhou, Zhiguang
Lin, Lixiang
Wang, Na
Yang, Wenying
AffiliationChina Japan Friendship Hosp, Dept Endocrinol, Beijing, Peoples R China.
Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing, Peoples R China.
Sun Yat Sen Univ, Hosp 3, Dept Endocrinol, Guangzhou 510275, Guangdong, Peoples R China.
Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Endocrinol, Shanghai 200030, Peoples R China.
Peking Univ, Peoples Hosp, Dept Endocrinol, Beijing 100871, Peoples R China.
Chinese Med Univ, Affiliated Hosp 1, Dept Endocrinol, Liaoling, Peoples R China.
Shanxi Prov Peoples Hosp, Dept Endocrinol, Taiyuan, Shanxi, Peoples R China.
Sichuan Univ, West China Hosp, Dept Endocrinol, Chengdu 610064, Sichuan, Peoples R China.
Fourth Mil Med Univ, Xijing Hosp, Dept Endocrinol, Xian 710032, Shanxi, Peoples R China.
Nanjing Univ, Sch Med, Affiliated Drum Tower Hosp, Dept Endocrinol, Nanjing 210008, Jiangsu, Peoples R China.
Xinjiang Uygur Autonomous Reg Hosp, Dept Endocrinol, Urumqi, Xinjiang, Peoples R China.
Shandong Univ, Qilu Hosp, Dept Endocrinol, Jinan 250100, Shandong, Peoples R China.
Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100871, Peoples R China.
Henan Prov Peoples Hosp, Dept Endocrinol, Zhengzhou, Henan, Peoples R China.
Harbin Med Univ, Affiliated Hosp 2, Dept Endocrinol, Harbin, Heilongjiang, Peoples R China.
Xiangya Second Hosp, Dept Endocrinol, Changsha, Hunan, Peoples R China.
Fujian Prov Hosp, Dept Endocrinol, Fuzhou, Fujiang, Peoples R China.
Issue Date2015
Publisherplos one
CitationPLOS ONE.2015,10,(2).
AbstractAim To investigate the association between different family history risk categories and prevalence of diabetes in the Chinese population. Methods The family history of diabetes was obtained from each subject, and an oral glucose tolerance test was performed for measuring the fasting and postload glucose and insulin levels based on a national representative cross-sectional survey of 46,239 individuals (age >= 20 years) in the 2007-2008 China National Diabetes and Metabolism Disorders Study. The family history risk categories of diabetes were high, moderate, and average (FH2 and FH1: at least two generations and one generation of first-degree relatives with diabetes, respectively; FH0: no first-degree relatives with diabetes). Results The age-and gender-adjusted prevalence rates of diabetes were 32.7% (95% confidence interval (CI): 26.4-39.7%) in FH2, 20.1% (95% CI: 18.2-22.1%) in FH1, and 8.4% (95% CI: 7.9-8.9%) in FH0 (P < 0.0001). The calculated homeostatic model assessment-estimated insulin resistance (HOMA-IR), Matsuda insulin sensitivity index (ISI), and insulinogenic index (Delta I30/Delta G30) values showed significant trending changes among the three risk categories, with the most negative effects in FH2. Multivariate logistic regression analysis showed that the odds ratios of having diabetes were 6.16 (95% CI: 4.46-8.50) and 2.86 (95% CI: 2.41-3.39) times higher in FH2 and FH1, respectively, than in FH0 after adjustment for classical risk factors for diabetes. Conclusions Family history risk categories of diabetes have a significant, independent, and graded association with the prevalence of this disease in the Chinese population.
Appears in Collections:人民医院

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