香豆素衍生物和β环糊精分子络合过程的稳态和时间分辨荧光研究

Abstract

用稳态和时间分辨荧光光谱法研究某些香豆素衍生物(C311,C47,C102,C120和C4)同βCyD在水溶液中的络合过程。观察到这些分子在βCyD水溶液中的荧光峰值兰向位移、强度增加和荧光寿命增大。结果表明CND分子在水溶液中同βCyD分子发生络合作用。测得的CND一βCyD体系的络合常数按下列次序递减;K_311>K_47>K_102>K_120>K_4,这些事实揭示了客体分子的憎水性及同βCyD分子腔体尺寸医配是影响络合作用的重要因素。

The complexation of some Coumarin derivatives (C-311, C-47, C-102, C-120 and C-4) With beta-CyD in aqueous solution has been examined by means of steady-state and time resolved fluorescence methods. It is observed that the fluorescence peaks, relative intensities and lifetimes of the guest molecules in aqueous solution of beta-CyD reveal hypsochromic shift, enhancement and increment respectively relative to those of guest molecules in aqueous solution. The results indicate that the CNDs complex with beta-CyD to a certain extent. The measured complexation constants for CND-beta-CyD systems decrease in the order of K-S11 K-47 K-102 K-120 K-4. These facts reflect that the hydrophobic property of guest molecule and the matching size between the guest molecule and beta-CyD are important factors affecting their complexation.