TitleAntiglomerular Basement Membrane Disease Associated With Castleman Disease
AuthorsLv, Jicheng
Zhang, Hong
Zhou, Fude
Zou, Wanzhong
Singh, Ajay K.
Wang, Haiyan
AffiliationPeking Univ, Hosp 1, Inst Nephrol, Div Renal, Beijing 100871, Peoples R China.
Brigham & Womens Hosp, Div Renal, Boston, MA 02115 USA.
Peking Univ, Hosp 1, Inst Nephrol, Div Renal, 8 Xishiku St, Beijing 100871, Peoples R China.
KeywordsAntiglomerular basement membrane antibodies
Castleman disease
Crescentic glomerulonephritis
LYMPH-NODE HYPERPLASIA
ANTIBODY
Issue Date2009
Publisheramerican journal of the medical sciences
CitationAMERICAN JOURNAL OF THE MEDICAL SCIENCES.2009,337,(3),206-209.
AbstractWe described a 33-year-old man with gross hematuria and acute renal failure, who had suffered from fever for 6 months, multiple cervical lymph node swelling, splenomegaly, left-sided pleural effusion. He also suffered from anemia, thrombocytopenia, hypergamma-globulinemia, and his serum interleukin-6 levels were markedly elevated. Antiglomerular basement membrane antibodies were positive in the patient's serum. Lymph node biopsy results were compatible with Castleman disease of "plasma cell" variant. Renal biopsy revealed cellular crescents in most of the glomeruli. Immunofluorescence Studies showed strong deposition of IgG in a linear pattern along the glomerular basement membrane. Pathologic features were compatible with crescentic glomerulonephritis because of antiglomerular basement membrane disease. With intensive plasmapheresis and monthly chemotherapy (cyclophosphamide, oncovin, prednisone regimen), the patient experienced clinical and biochemical remission. Although autoimmune phenomenon had been described frequently in Castleman disease, to the best of our knowledge, this was the first report that the patient with rapid progressive glomerulonephritis mediated by antiglomerular basement membrane antibodies, which might be associated with Castleman disease.
URIhttp://hdl.handle.net/20.500.11897/396631
ISSN0002-9629
IndexedSCI(E)
Appears in Collections:第一医院

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