Title肝炎对结直肠癌肝转移外科治疗及预后的影响
Other TitlesEffect of hepatitis on surgical treatment and prognosis of colorectal liver metastasis
Authors刘铭
王崑
孙谊
包全
王宏伟
金克敏
邢宝才
Affiliation100142,北京大学肿瘤医院暨北京市肿瘤防治研究所肝胆胰外一科 恶性肿瘤发病机制及转化研究教育部重点实验室
Keywords肝炎
结直肠癌肝转移
外科治疗
预后
Hepatitis
Colorectal liver metastases
Surgical treatment
Prognosis
Issue Date2015
Publisher中华胃肠外科杂志
Citation中华胃肠外科杂志.2015,(7),680-683.
Abstract目的:探讨肝炎对结直肠癌肝转移(CRLM)患者外科治疗及预后的影响。方法回顾性分析2007年11月至2013年1月,于北京大学肿瘤医院肝胆胰外一科行手术治疗的175例CRLM患者的临床资料,根据是否合并肝炎,分为合并肝炎组(16例)和未合并肝炎组(159例)比较两组患者围手术期肝功能、手术方式及预后。结果除血小板水平合并肝炎组明显低于未合并肝炎组外(P<0.05),其他肝功能指标(血清白蛋白、总胆红素及凝血酶原时间)两组差异均无统计学意义(均P>0.05)。两组患者中行大范围肝转移灶切除术的比例分别为37.5%(6/16)和22.0%(35/159),差异无统计学意义(P>0.05)。手术时间、术中出血量、术后胆漏发生率及术后引流量等围手术期指标两组差异亦无统计学意义(均P>0.05)。两组患者术后中位总生存时间分别为46月和33月,中位无瘤生存时间分别为8月和10月,差异均无统计学意义(均P>0.05)。结论合并肝炎的CRLM患者肝储备功能良好,可以安全地进行大范围肝切除,不会影响生存。
Objcetive To evaluate the effect of hepatitis on surgical treatment and prognosis of colorectal liver metastasis(CRLM). Methods A retrospective study of medical records of all the patients undergoing operation with colorectal liver metastasis in Peking University Hepatobiliary pancreatic Surgery Ward I from November 2007 to January 2013 was conducted. A total of 175 patients were eligible and divided into two groups: with hepatitis (n=16) or without hepatitis (n=159). Results Preoperative liver function was similar in these two groups. There were no significant differences in preoperative serum albumin, total bilirubin and prothrombin time between two groups (all P>0.05), except for lower blood platelet in hepatitis group after operation. Major hepatectomy was performed in 37.5%(6/16) and 22.0%(15/159) of two groups respectively (P>0.05). There were also no significant differences in operation time, blood loss, surgical complications and drainage volume (all P>0.05). The median overall survival time was 46 months in hepatitis group and 33 months in non-hepatitis group, and the median disease free time was 8 months in hepatitis group and 10 months in non-hepatitis group (all P>0.05). Conclusion CRLM patients concomitant with hepatitis have adequate liver reserve function for major hepatic resection and have similar prognosis of patients without hepatitis.
URIhttp://hdl.handle.net/20.500.11897/414456
ISSN1671-0274
DOI10.3760/cma.j.issn.1671-0274.2015.07.012
IndexedPubMed
中文核心期刊要目总览(PKU)
中国科技核心期刊(ISTIC)
中国科学引文数据库(CSCD)
Appears in Collections:北京肿瘤医院

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