| Title | Biomimetic Intrafibrillar Mineralization of Type I Collagen with Intermediate Precursors-loaded Mesoporous Carriers |
| Authors | Zhang, Wei Luo, Xiao-juan Niu, Li-na Yang, Hong-ye Yiu, Cynthia K. Y. Wang, Tian-da Zhou, Li-qun Mao, Jing Huang, Cui Pashley, David H. Tay, Franklin R. |
| Affiliation | Huazhong Univ Sci & Technol, Tongji Hosp, Wuhan 430074, Peoples R China. Fourth Mil Med Univ, Sch Stomatol, Dept Prosthodont, State Key Lab Mil Stomatol, Xian 710032, Peoples R China. Wuhan Univ, Wuhan 430072, Peoples R China. Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China. Peking Univ, Sch & Hosp Stomatol, Beijing 100871, Peoples R China. Georgia Regents Univ, Augusta, GA 30912 USA. |
| Keywords | CALCIUM-PHOSPHATE PRENUCLEATION CLUSTERS SILICA NANOPARTICLES DRUG-DELIVERY ADSORPTION NUCLEATION POLYMER SURFACE FIBRILS WATER |
| Issue Date | 2015 |
| Publisher | SCIENTIFIC REPORTS |
| Citation | SCIENTIFIC REPORTS.2015,5. |
| Abstract | Limited continuous replenishment of the mineralization medium is a restriction for in-situ solution-based remineralization of hypomineralized body tissues. Here, we report a process that generated amine-functionalized mesoporous silica nanoparticles for sustained release of biomimetic analogstabilized amorphous calcium phosphate precursors. Both two-dimensional and three-dimensional collagen models can be intrafibrillarly mineralized with these released fluidic intermediate precursors. This represents an important advance in the translation of biomineralization concepts into regimes for in-situ remineralization of bone and teeth. |
| URI | http://hdl.handle.net/20.500.11897/419404 |
| ISSN | 2045-2322 |
| DOI | 10.1038/srep11199 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 口腔医院 |
