红细胞计数与肝功能状态的关联性分析

Abstract

目的 比较不同肝病患者的红细胞计数的变化,探讨红细胞计数与肝损害程度的关系.方法 收集1 427例原发性肝癌患者,172例肝硬化患者和185例肝炎患者的临床资料,并对其进行Child-Pugh分级.回顾性分析不同肝病患者红细胞计数的差异,探讨红细胞计数与肝功能状态的关联.据资料不同分别采用Mann-Whitney U检验、Kruskal Wallis H检验、秩和检验、Spearman秩和相关检验、x2检验.结果 慢性肝炎患者、肝癌患者和肝硬化患者的红细胞计数差异具有统计学意义,且慢性肝炎＞肝癌＞肝硬化(P＜ 0.05).肝硬化患者中,红细胞计数在Child-Pugh分级较高的患者中倾向于降低(P＜0.05). 结论 红细胞计数可反映肝硬化患者的肝损害程度,或可为完善肝硬化患者的肝功能预测模型提供依据.

Objective To investigate the changes in red blood cell count in patients with different liver diseases and the correlation between red blood cell count and degree of liver damage.Methods The clinical data of 1427 patients with primary liver cancer,172 patients with liver cirrhosis,and 185 patients with hepatitis were collected,and the Child-Pugh class was determined for all patients.The differences in red blood cell count between patients with different liver diseases were retrospectively analyzed,and the correlation between red blood cell count and liver function status was investigated.The Mann-Whitney U test,KruskalWallis H test,rank sum test,Spearman rank sum correlation test,and chi-square test were performed for different types of data.Results Red blood cell count showed significant differences between patients with chronic hepatitis,liver cancer,and liver cirrhosis and was highest in patients with chronic hepatitis and lowest in patients with liver cirrhosis (P ＜ 0.05).In the patients with liver cirrhosis,red blood cell count tended to decrease in patients with a higher Child-Pugh class (P ＜ 0.05).Conclusion For patients with liver cirrhosis,red blood cell count can reflect the degree of liver damage,which may contribute to an improved liver function prediction model for these patients.