TitleF-127-PEI co-delivering docetaxel and TFPI-2 plasmid for nasopharyngeal cancer therapy
AuthorsLiu, Tao
Zhang, Xinyu
Ke, Bo
Wang, Yigang
Wu, Xidong
Jiang, Gang
Wu, Ting
Nie, Guohui
AffiliationSouthern Med Univ, Zhujiang Hosp, Dept Otolaryngol, Guangzhou 510282, Guangdong, Peoples R China.
Jiangxi Prov Peoples Hosp, Jiangxi Key Lab Hematol Oncol & Cell Biol, Nanchang 330006, Peoples R China.
Zhejiang Sci Tech Univ, Sch Life Sci, Hangzhou 310018, Zhejiang, Peoples R China.
Jiangxi Inst Mat Med, Dept Pharmacol, Nanchang 330029, Peoples R China.
Guangdong Polytech, Dept Light Chem Engn, Foshan 528041, Peoples R China.
Peking Univ, Shenzhen Hosp, Dept Otolaryngol, Shenzhen 518036, Peoples R China.
Southern Med Univ, Zhujiang Hosp, Dept Otolaryngol, Guangzhou 510282, Guangdong, Peoples R China.
Nie, GH (reprint author), Peking Univ, Shenzhen Hosp, Dept Otolaryngol, Shenzhen 518036, Peoples R China.
KeywordsTFPI-2
Docetaxel
Co-delivery
Nasopharyngeal cancer
ANTICANCER DRUG
GROWTH-FACTOR
LUNG-CANCER
CELLS
POLYETHYLENIMINE
SIRNA
NANOPARTICLES
COPOLYMERS
CARCINOMA
TOXICITY
Issue Date2016
PublisherMATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
CitationMATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS.2016,61,269-277.
AbstractThe co-delivery of drug and gene has become the primary strategy in cancer therapy. However, to construct one safe co-delivering system with higher drug loading and gene transfection efficiency for cancer therapy is still challenging. Herein, a novel degradable nanocarriers were synthesized and characterized in this study, which was composed of polyethylenimine (PEI)-linked PEO-PPO-PEO (Pluronic F127), called F127-PEI. Then the nanocarrier was used for hydrophobic docetaxel (DOC) and functional gene (TFPI-2 plasmid) co-delivery to treat nasopharyngeal cancer (NPC). The results indicated that F127-PEI nanocarriers had higher DOC loading amount and possessed good gene delivery effect in vitro. For co-delivery analysis, the obtained F127-PEI/DOC/TFPI-2 complexes could induce a more significant apoptosis than DOC or TFPI-2 alone, and decreased invasive capacity of NPC HNE-1 cells more obviously. Moreover, the F127-PEI copolymer exhibited better blood compatibility and lower cytotoxicity compared to PEI-25k by the hemolysis and MTT assays, which suggests a promising potential for NPC therapy. (C) 2015 Elsevier B.V. All rights reserved.
URIhttp://hdl.handle.net/20.500.11897/435099
ISSN0928-4931
DOI10.1016/j.msec.2015.12.049
IndexedSCI(E)
EI
PubMed
Appears in Collections:深圳医院

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