Title18F-FDG PET对睾丸生殖细胞肿瘤化疗后肿瘤残留的准确性判断
Other TitlesThe 18F-fluorodeoxyglucose positron emission tomograhy in predicting residual retro-peritoneal tumor after chemotherapy of testis germ cell tumors
Authors王硕
杜鹏
汤星星
安超
赵强
张宁
杨勇
Affiliation北京大学肿瘤医院暨北京市肿瘤防治研究所泌尿外科,恶性肿瘤发病机制及转化研究教育部重点实验室 北京市,100142
Keywords18F-FDG
PET
睾丸生殖细胞肿瘤
腹膜后淋巴结清扫术
18F-fluorodeoxyglucose positron emission tomography
testis germ cell tumors
retroperitoneal lymph nodes dissection
Issue Date2017
Publisher中国肿瘤临床
Citation中国肿瘤临床. 2017, 44(12), 608-611.
Abstract目的:探讨睾丸生殖细胞肿瘤化疗后18F-FDG PET对腹膜后残留病灶的准确性判断.方法:回顾性分析2014年2月至2016年12月北京大学肿瘤医院泌尿外科16例睾丸生殖肿瘤伴腹膜后淋巴结转移患者的资料,4~6个疗程的博来霉素+顺铂+依托泊苷(BEP)化疗后行腹部CT检查,所有患者的腹膜后肿块直径>2 cm.18F-FDG PET检查后行腹膜后淋巴结清扫术,并进行术后病理与术前18F-FDG PET结果比较.结果:16例患者中10例18F-FDG PET结果阳性,其中5例术后病理存在肿瘤残留、5例无肿瘤残留组织;6例18F-FDG PET结果为阴性,2例术后病理肿瘤残留患者均为成熟畸胎瘤、4例无肿瘤组织残留.18F-FDG PET的准确率为56.25%(9/16),灵敏度为71.42%(5/7),特异度为44.44%(4/9),阳性预测率为50.00%(5/10),阴性预测率为66.67%(4/6).结论:18F-FDG PET灵敏度较高,但多种因素会影响18F-FDG PET结果的准确性,成熟畸胎瘤易造成18F-FDG PET的假阴性,大量炎性组织易造成18F-FDG PET假阳性,需结合多种检查提高结果准确性.
Objective:To determine the value of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) scans in identify-ing the residual retroperitoneal tumor after chemotherapy of testis germ cell tumors. Methods:Sixteen testis germ cell tumor patients with metastasis of retroperitoneal lymph nodes who were treated in our hospital from February 2014 to December 2016 were select-ed for the study from February 2014 to December 2016. After 4-6 cycles of chemotherapy, their CT scans showed residual masses with diameters greater than 2 cm. The retroperitoneal lymph nodes were dissected after the 18F-FDG PET exam. The post-surgery pathology results were compared with the results of the 18F-FDG PET exam. Results:Residual tumors were found in 5 of 10 patients with 18F-FDG PET positive. Residual tumor was absent in 4 of 6 patients with 18F-FDG PET negative, while residual mature teratoma tumors were found in two patients. The accuracy rate, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the 18F-FDG PET exam were 56.25%(9/16), 71.42%(5/7), 44.44%(4/9), 50.00%(5/10), and 66.67%(4/6), respectively. Conclusion: 18F-FDG PET is highly sensitive. However, many factors influence the result of 18F-FDG PET. Mature teratoma leads to a false negative re-sult, whereas massive tissue inflammation leads to a false positive result. Therefore, more clinical examinations should be made.
URIhttp://hdl.handle.net/20.500.11897/465719
ISSN1000-8179
DOI10.3969/j.issn.1000-8179.2017.12.225
Indexed中国科学引文数据库(CSCD)
Appears in Collections:北京肿瘤医院

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