伴焦虑症状双相障碍患者自杀未遂的危险因素分析

Abstract

目的 探讨伴焦虑症状双相障碍患者自杀未遂的危险因素.方法 选取245例伴有焦虑症状的双相障碍患者,通过简明国际神经精神访谈(MINI)的自杀模块,分为自杀未遂组和无自杀未遂组,采用Logistic回归分析伴焦虑症状双相障碍患者自杀未遂的危险因素.结果 伴焦虑症状双相障碍患者的自杀未遂发生率为24.5％.与无自杀未遂组患者相比,自杀未遂组患者既往发病次数和住院次数更多,抑郁发作更频繁,更常伴有不典型特征、自杀观念、精神病性症状、季节性特征(P＜0.05),以及更常使用抗抑郁剂治疗(P＜0.05).多因素Logistic回归分析显示,自杀观念与伴焦虑症状双相障碍患者发生自杀未遂相关(P＜0.05).结论 伴有自杀观念是伴焦虑症状双相障碍患者自杀未遂的主要危险因素.

Objective To explore the risk factors for attempted suicide in bipolar disorder patients with anxious symptoms.Methods A total of 245 bipolar disorder patients with anxious symptoms were divided into attempted suicide group and non-attempted suicide group through suicide module of Mini International Neuropsychiatric Interview (MINI) and assessed with multiple logistic regression analysis for risk factors of attempted suicide.Results It was 24.5％ for the rate of attempted suicide in bipolar disorder patients with anxious symptoms.Compared with non-attempted suicide group,there were more times of onset and admission,more depressive episodes,more atypical characteristics,more suicidal ideations,more psychotic symptoms,more seasonal characteristics and more antidepressant use in attempted suicide group (P ＜ 0.05).The results of multiple logistic regression analysis showed that suicidal ideation was significantly associated with attempted suicide in bipolar disorder patients with anxious symptoms (P ＜ 0.05).Conclusions Suicidal ideation may be considered as potential risk factor for attempted suicide in bipolar disorder patients with anxious symptoms.