TitleHuman U Three Protein 14a Expression is Increased in Hepatocellular Carcinoma and Associated with Poor Prognosis
AuthorsZhang, Jing-Yi
Xu, Da
Liu, Zhen-Zhen
Li, Yuan
Wang, Li-Jun
Xing, Bao-Cai
AffiliationPeking Univ Canc Hosp & Inst, Hepatopancreatobiliary Surg Dept 1, Key Lab Carcinogenesis & Translat Res, Minist Educ, 52 Fu Cheng Rd, Beijing 100142, Peoples R China.
KeywordsHepatocellular Carcinoma
Human U Three Protein 14a
Poor Prognosis
HEPATIC-RESECTION
TUMOR SIZE
SURVIVAL
ACTIVATION
THROMBOSIS
MARKER
P53
Issue Date2017
PublisherChinese Medical Journal
CitationCHINESE MEDICAL JOURNAL.2017,130(4),470-476.
AbstractBackground: HumanUthree protein 14a(hUTP14a) promotes p53 degradation. Moreover, hUTP14a expression is upregulated in several types of tumors. However, the expression pattern of hUTP14a in hepatocellular carcinoma (HCC) remains unknown. The aim of this study was to investigate hUTP14a expression and its prognostic value in HCC. Methods: The hUTP14a expression was evaluated using immunohistochemistry (IHC) in HCC tissue specimens. The correlations between hUTP14a expression and clinicopathological variables were analyzed. The Kaplan-Meier method was used to analyze the association between hUTP14a expression and survival. Independent prognostic factors associated with overall survival (OS) and disease-free survival (DFS) were analyzed using the Cox proportional-hazards regression model. Results: The IHC data revealed that the hUTP 14a positivity rate in HCC tissue specimens was significantly higher than that in nontumorous tissue specimens (89.9% vs. 72.7%, P < 0.05). The hUTP14a expression was detected in both the nucleolus and the cytoplasm. The positivity rate of nucleolar hUTP14a expression in HCC tissue specimens was higher than that in the nontumorous tissue specimens (29.3% vs. 10.1%, P < 0.05). No significant difference was found between HCC and nontumorous tissue specimens of cytoplasmic hUTP 14a expression (6 0. 6% vs. 62.6%, P > 0.05). In addition, no significant correlation was found between nucleolar hUTP 14a expression and other clinicopathological variables. The 5-year OS and DFS rates in patients with positive nucleolar hUTP14a expression were significantly lower than those in patients with negative hUTP14a expression (P = 0.004 for OS, P= 0.003 for DFS). Multivariate analysis showed that nucleolar hUTP14a expression was an independent prognostic factor for OS (P = 0.004) and DFS (P < 0.001). Conclusions: The positivity rate of hUTP14a expression was significantly higher in HCC specimens. Positive expression of nucleolar hUTP14a might act as a novel prognostic predictor for patients with HCC.
URIhttp://hdl.handle.net/20.500.11897/475084
ISSN0366-6999
DOI10.4103/0366-6999.199839
IndexedSCI(E)
Appears in Collections:北京肿瘤医院

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