Title2型糖尿病患者颈动脉和下肢动脉粥样硬化分级与心脑血管疾病关系的研究
Other TitlesAssociation of carotid artery and lower-extremity artery atherosclerosis and coronary heart disease or cerebral infarction in type 2 diabetes
Authors刘珊
周翔海
胡萍
庞梦端
段妍
刘艳
刘越素
许林鑫
Affiliation石家庄市第二医院内分泌科
100044北京大学人民医院内分泌科
山西医科大学第二附属医院内分泌科, 太原,030001
山西医科大学第一附属医院内分泌科,太原,030001
Keywords糖尿病,2型
动脉粥样硬化
冠心病
脑梗塞
颈动脉分级
Diabetes mellitus,type 2
Atherosclerosis
Coronary heart disease
Cerebral infarction
Carotid artery degree
Issue Date2016
Publisher中华内分泌代谢杂志
Citation中华内分泌代谢杂志. 2016, 32(12), 989-994.
Abstract目的研究住院2型糖尿病患者颈动脉和下肢动脉粥样硬化分级与心脑血管疾病的关系。方法收集1503例平均年龄(55.8±12.9)岁的住院2型糖尿病患者病历资料,采用血管彩超检查评估颈动脉和下肢动脉内-中膜厚度、粥样硬化斑块和管腔直径,依动脉粥样硬化程度分为4级:无动脉粥样硬化(1级);动脉内-中膜增厚(2级);粥样硬化斑块形成(3级);动脉狭窄≥20%(4级)。冠心病及脑梗塞病史来自病历记录。采用logistic多因素回归分析颈动脉和下肢动脉粥样硬化分级与冠心病、脑梗塞的相关性。结果多因素调整后回归分析显示,与颈动脉1级患者比较,颈动脉3级和4级患者的冠心病患病风险增加[OR=2.30(95%CI 1.17~4.53),OR=4.05(95% CI 1.88~8.74)],脑梗塞患病风险增加[OR=1.95(95%CI 1.22~3.10),OR=2.68(95%CI 1.50~4.77)]。与下肢动脉1级患者比较,下肢动脉3和4级患者冠心病患病风险增加[OR=2.39(95%CI 0.99~5.74),OR=4.10(95%CI 1.44~11.67)];下肢动脉2、3和4级患者脑梗塞患病风险增加[OR=2.20(95%CI 1.05~4.63),OR=3.60(95%CI 1.82~7.10)和OR=3.15(95%CI 1.32~7.50)]。与颈动脉和下肢动脉分级均为1或2级患者相比,颈动脉和下肢动脉分级均为3或4级的患者,冠心病和脑梗塞的患病风险均增高;而仅有一个部位动脉分级为3或4级者,其冠心病和脑梗塞患病风险无明显增高。结论可以采用简单的动脉硬化分级方法评估2型糖尿病患者颈动脉或下肢动脉粥样硬化程度。如同时评估颈动脉和下肢动脉粥样硬化,仅当两者均出现斑块或狭窄时,冠心病或脑梗塞的患病风险显著增高。
cerebral infarction as compare with patients at Grade 1-2 in both vascular locations, whereas the risk was not significantly increased in patients at Grade 3-4 in only one vascular location. Conclusions The simple method of assessing the degree of arterial atherosclerosis can be used to evaluate carotid artery and lower-extremity artery atherosclerosis in patients with type 2 diabetes. Patients with plaques or stenosis in both vascular locations were with a significantly increased risk of coronary heart disease or cerebral infarction if they were evaluated concurrently.
URIhttp://hdl.handle.net/20.500.11897/478052
ISSN1000-6699
DOI10.3760/cma.j.issn.1000-6699.2016.12.003
Indexed中文核心期刊要目总览(PKU)
中国科技核心期刊(ISTIC)
中国科学引文数据库(CSCD)
Appears in Collections:人民医院

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