体外膜氧合对不同人群药动学影响的研究进展

Abstract

体外膜氧合是一种应用于重症患者的重要体外生命支持手段,这一技术可能对药物的分布、代谢、清除乃至药效产生影响.早期研究体外膜氧合对药动学的影响主要针对儿童群体,近年来国内外的研究开始关注更多药物及成人群体.本文对体外膜氧合影响不同人群药动学的研究结果进行总结,并提出对未来研究的建议.

Extracorporeal membrane oxygenation(ECMO) is applied in critical patients as a vital extracorporeal life support system.The technique may have influence on distribution,metabolism,clearance and efficacy of drugs.Early studies on pharmacokinetics during ECMO mainly focused on pediatric patients while recent researches included adults and multiple drugs.This article reviewed impact of ECMO on pharmacokinetics in different populations and offered suggestions for future studies.