TitleApplication of receiver operating characteristic curve in the assessment of the value of body mass index, waist circumference and percentage of body fat in the Diagnosis of Polycystic Ovary Syndrome in childbearing women
AuthorsDou, Pan
Ju, Huiyan
Shang, Jing
Li, Xueying
Xue, Qing
Xu, Yang
Guo, Xiaohui
AffiliationPeking Univ, Hosp 1, Dept Clin Nutr, Beijing, Peoples R China.
Peking Univ, Hosp 1, Ctr Reprod & Genet, Beijing, Peoples R China.
Peking Univ, Hosp 1, Dept Biostat, Beijing, Peoples R China.
Peking Univ, Hosp 1, Dept Endocrinol, Beijing, Peoples R China.
7 Xishiku Rd, Beijing 100034, Peoples R China.
Peking Univ, Hosp 1, Ctr Reprod & Genet, Beijing, Peoples R China.
Guo, XH (reprint author), Peking Univ, Hosp 1, Dept Endocrinol, Beijing, Peoples R China.
KeywordsChildbearing age
Polycystic ovary syndrome
Obesity
Body mass index
Waist circumference
percentage of body fat
Receiver operating characteristic
Area under the curve
METABOLIC SYNDROME
WEIGHT-LOSS
ANTHROPOMETRIC INDEXES
OBESITY PARADOX
RISK-FACTORS
PREVALENCE
DISEASE
DIET
METAANALYSIS
ASSOCIATION
Issue Date2016
PublisherJOURNAL OF OVARIAN RESEARCH
CitationJOURNAL OF OVARIAN RESEARCH.2016,9.
AbstractBackground: There are various parameters to analyze obesity, however, no standard reference to predict, screen or diagnose PCOS with various obesity parameters has been established, and the accuracy of these parameters still needs to be studied. This study was to use the receiver operating characteristic (ROC) curve to explore the different values of three obesity parameters, body mass index (BMI), waist circumference (WC) and percentage of body fat (PBF) in the diagnosis of polycystic ovary syndrome (PCOS) in Chinese childbearing women. Methods: Three hundred patients who were diagnosed with PCOS at Center of Reproductive Medicine and Genetics of Peking University First Hospital were enrolled in this study, and 110 healthy age-matched women were enrolled as controls. The characteristics of BMI, WC and PBF in PCOS patients were analyzed. Results: Compared with the control group, all the three obesity parameters were significantly increased in PCOS group. In terms of ROC area under the curve, WC > PBF > BMI, and they were all significantly different from those of the control. At a cut-off point of 80.5 cm, WC has a sensitivity of 73.6 % and a specificity of 85 % in diagnosis of PCOS; At a cut-off point of 29 %, PBF has a sensitivity of 88.2 % and a specificity of 57.7 % in diagnosis of PCOS; and at a cut-off point of 26.6 kg/m(2), BMI has a sensitivity of 54.5 % and a specificity of 98 % in diagnosis of PCOS. Conclusion: WC, BMI and PBF are valuable in screening and diagnosis of PCOS in Chinese childbearing women. PBF can be used to screen PCOS as it has a better sensitivity, while BMI can be used in the diagnosis of PCOS as it has a better specificity.
URIhttp://hdl.handle.net/20.500.11897/491542
ISSN1757-2215
DOI10.1186/s13048-016-0260-9
IndexedSCI(E)
PubMed
Appears in Collections:第一医院

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