Title糖尿病合并高血压患者血糖、血压水平与动脉硬化的相关性研究
Other TitlesRelationship between Arterial Stiffness and Blood Glucose/Blood Pressure in Diabetic Patients with Hypertension
Authors杨燕芬
曹亚英
孙可欣
刘志科
项骁
隽娟
宋菁
黄少平
刘晓芳
李娜
唐迅
李劲
吴涛
陈大方
胡永华
Affiliation100191,北京大学公共卫生学院流行病与卫生统计学系
102401,北京市房山区疾病预防控制中心办公室
102401,北京市房山区疾病预防控制中心慢性病防治科
北京市房山区科学技术委员会办公室
Keywords肱踝脉搏波传导速度
糖尿病2型
高血压
血红蛋白A
糖基化
血压
Brachial-ankle pulse wave velocity
Type 2 diabetes mellitus
Hypertension
Hemoglobin A
Glycosylated
Blood pressure
Issue Date2017
Publisher医学研究杂志
Citation医学研究杂志. 2017, 46(9), 25-30.
Abstract目的 探讨糖尿病合并高血压患者血糖血压水平与动脉硬化的关系.方法 以北京某农村社区40岁及以上糖尿病合并高血压患者为研究对象,对患者进行问卷调查、体格检查、肱踝脉搏波传导速度(baPWV)检测和血样检测.根据患者糖化血红蛋白(HbA1c)、收缩压(SBP)及舒张压(DBP)水平进行分组,采用Logistic回归模型分析血糖血压水平与动脉硬化的关系.结果 共纳入1214例患者,其中动脉硬化异常(baPWV≥1700cm/s)有637人,占52.47%.相关性分析显示baPWV与HbA1c(rs=0.174,P=0.000)、SBP(rs=0.481,P=0.000)及DBP(rs=0.167,P=0.000)均呈正相关.Logistic回归分析显示,调整其他危险因素后,HbA1c和SBP每增加1个四分位数间距动脉硬化异常风险分别为1.41倍(95% CI:1.16~1.70)和3.71倍(95%CI:2.80~4.91).结论 糖尿病合并高血压患者baPWV与HbA1c及SBP显著相关,同时控制血糖和血压可能有利于降低动脉硬化异常发生风险.
Objective To investigate the relationship between arterial stiffness and blood glucose or blood pressure in community patients with diabetes mellitus and hypertension.Methods Diabetic patients with hypertension aged 40 or above were enrolled from rural communities of Beijing.Every patient completed a standardized questionnaire and underwent physical examinations,brachial-ankle pulse wave velocity (baPWV) measurements,blood tests.Patients were divided into groups according to the level of glycated hemoglobin (HbA1c),systolic blood pressure (SBP) and diastolic blood pressure (DBP).Analyses were performed by using multiple logistic regression model to explore the relationship between baPWV and blood glucose/blood pressure.Results Among 1214 patients enrolled,the detection rate of arterial stiffness (baPWV≥ 1700cm/s) was 52.47%.Correlation analysis showed baPWV was positively associated with HbA1c (rs =0.174,P=0.000),SBP (rs =0.481,P=0.000) and DBP (rs =0.167 P=0.000).After multivariable adjustment,an increase of one IQR (from 25th to the 75th percentile) in the HbA1 c and SBP was associated with greater risk of arterial stiffness [HbA1c (an increase of 2%):OR=1.41 (95% CI:1.16-1.70);SBP (an increase of 23mmHg):OR=3.71 (95% CI:2.80-4.91)].Conclusion The blood glucose/blood pressure was associated with baPWV among diabetic patients with hypertension.Combined efforts to improve both blood pressure and glycemic control may help to reduce the risk of arterial stiffness.
URIhttp://hdl.handle.net/20.500.11897/498932
ISSN1673-548X
DOI10.11969/j.issn.1673-548X.2017.09.008
Appears in Collections:公共卫生学院

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