TitleN terminal N-methylation modulates chiral centre induced helical (CIH) peptides' biophysical properties.
AuthorsLi, Wenjun Hu, Kuan Zhang, Qingzhou Wang, Dongyuan Ma, Yue Hou, Zhanfeng Yin, Feng Li, Zigang
AffiliationThe Key Laboratory of Chemical Genomics School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China518055. yinfeng@pkusz.edu.cn lizg@pkusz.edu.cn.
KeywordsTARGET BINDING-AFFINITY
STAPLED PEPTIDES
CHEMICAL-SYNTHESIS
CYCLIC-PEPTIDES
PEPTOID MIMICS
CELL
PERMEABILITY
LIGATION
HIF-1
MACROCYCLIZATION
Issue Date2018
PublisherChemical communications (Cambridge, England)
CitationChemical communications (Cambridge, England). 2018, 54(15).
AbstractThe effects of N-methylation on CIH peptides' biophysical properties were systematically studied. N-Methylation at the N terminal NH could help improve the peptides' cellular uptake with a retained helical conformation. This N-methylation strategy could also be applied to longer peptides to improve their stability and cellular uptake.
URIhttp://hdl.handle.net/20.500.11897/505348
ISSN1364-548X
DOI10.1039/c7cc09201f
IndexedSCI(E)
PubMed
Medline
Appears in Collections:化学生物学与生物技术学院

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