Title挤压态Mg-5.25wt.%Zn-0.6wt.%Ca可降解镁合金的体内外研究(英文)
Authors顾雪楠
王凡
谢鑫荟
郑明毅
李萍
郑玉峰
秦岭
樊瑜波
AffiliationSchool of Biological Science and Medical Engineering, Beihang University
Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University
Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong
School of Materials science and Engineering, Harbin Institute of Technology
Department of Materials Science and Engineering, College of Engineering, Peking University
National Research Center for Rehabilitation Technical Aids
Keywordsmagnesium alloy
corrosion
biocompatibility
bone
biomaterial
Issue Date2018
PublisherScience China Materials
CitationScience China Materials. 2018, 619-628.
Abstract可降解医用镁合金在骨科领域显示出良好的应用前景.为了保证镁合金的生物相容性,本文设计了全营养元素组成的Mg-Zn-Ca合金,研究了其体内外腐蚀及生物相容性.Mg-Zn-Ca合金在五种模拟体液中的腐蚀测试结果表明在Hank’s和MEM中添加血清能够降低合金腐蚀速度,并提高腐蚀均匀性.血清浓度越高,合金腐蚀速率越低.Mg-Zn-Ca合金在MEM+10%FBS溶液中腐蚀速率低,腐蚀形貌均匀.直接法和间接法的细胞实验结果均显示Mg-Zn-Ca合金具有良好的细胞相容性.动物实验结果表明,Mg-Zn-Ca合金在小鼠骨髓腔内逐步降解,4周后残余40 vol.%.micro-CT和组织学观察显示植入体周围有新骨形成,且随着植入时间延长,皮质骨厚度增加.因此,挤压态Mg-Zn-Ca合金具有良好的生物相容性,有望用作骨科植入材料,但是其体内降解速率还应进一步降低.
URIhttp://hdl.handle.net/20.500.11897/530273
ISSN2095-8226
Appears in Collections:工学院

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