TitleCanagliflozin and Cardiovascular and Renal Outcomes in Type 2 Diabetes Mellitus and Chronic Kidney Disease in Primary and Secondary Cardiovascular Prevention Groups Results From the Randomized CREDENCE Trial
AuthorsMahaffey, Kenneth W.
Jardine, Meg J.
Bompoint, Severine
Cannon, Christopher P.
Neal, Bruce
Heerspink, Hiddo J. L.
Charytan, David M.
Edwards, Robert
Agarwal, Rajiv
Bakris, George
Bull, Scott
Capuano, George
de Zeeuw, Dick
Greene, Tom
Levin, Adeera
Pollock, Carol
Sun, Tao
Wheeler, David C.
Yavin, Yshai
Zhang, Hong
Zinman, Bernard
Rosenthal, Norman
Brenner, Barry M.
Perkovic, Vlado
Ahuad Guerrero, Rodolfo Andres
Aizenberg, Diego
Pablo Albisu, Juan
Alvarisqueta, Andres
Bartolacci, Ines
Alberto Berli, Mario
Bordonava, Anselmo
Calella, Pedro
Cecilia Cantero, Maria
Rodolfo Cartasegna, Luis
Cercos, Esteban
Cecilia Coloma, Gabriela
Colombo, Hugo
Commendatore, Victor
Cuadrado, Jesus
Alberto Cuneo, Carlos
Maria Cusumano, Ana
Guillermo Douthat, Walter
Dario Dran, Ricardo
Farias, Eduardo
Florencia Fernandez, Maria
Finkelstein, Hernan
Fragale, Guillermo
Osvaldo Fretes, Jose
Horacio Garcia, Nestor
Gastaldi, Anibal
Gelersztein, Elizabeth
Archibaldo Glenny, Jorge
Pablo Gonzalez, Joaquin
Gonzalez Colaso, Patricia del Carmen
Goycoa, Claudia
Cristian Greloni, Gustavo
Guinsburg, Adrian
Hermida, Sonia
Isaias Juncos, Luis
Isabel Klyver, Maria
Kraft, Florencia
Krynski, Fernando
Virginia Lanchiotti, Paulina
Alfonso Leon de la Fuente, Ricardo
Marchetta, Nora
Mele, Pablo
Nicolai, Silvia
Antonio Novoa, Pablo
Ines Orio, Silvia
Otreras, Fabian
Oviedo, Alejandra
Raffaele, Pablo
Hector Resk, Jorge
Rista, Lucas
Rodriguez Papini, Nelson
Sala, Jorgelina
Santos, Juan Carlos
Beatriz Schiavi, Lilia
Sessa, Horacio
Smith Casabella, Tomas
Rosa Ulla, Maria
Valdez, Maria
Vallejos, Augusto
Villarino, Adriana
Esther Visco, Virginia
Wassermann, Alfredo
Javier Zaidman, Cesar
Cheung, Ngai Wah
Droste, Carolyn
Fraser, Ian
Johnson, David
Mah, Peak Mann
Nicholls, Kathy
Packham, David
Proietto, Joseph
Roberts, Anthony
Roger, Simon
Tsang, Venessa
Raduan, Roberto Abrao
Alves da Costa, Fernando Augusto
Amodeo, Celso
Andreotti Turatti, Luiz Alberto
Bregman, Rachel
Camelo Sanches, Fernanda Cristina
Canani, Luis Henrique
Chacra, Antonio Roberto
Cunha Borges, Joao Lindolfo
Cunha Vencio, Sergio Alberto
da Silva Franco, Roberto Jorge
d'Avila, Domingos
Portes, Evandro de Souza
de Souza, Pedro
Deboni, Luciane Monica
Fraige Filho, Fadlo
Geloneze Neto, Bruno
Gomes, Marcus
Kohara, Suely Keiko
Keitel, Elizete
Kerr Saraiva, Jose Francisco
Kurtz Lisboa, Hugo Roberto
de Carvalho Contieri, Fabiana Loss
Milagres, Rosangela
Montenegro Junior, Renan
de Brito, Claudia Moreira
Hissa, Miguel Nasser
Nazario Sabbag, Angela Regina
Noronha, Irene
Panarotto, Daniel
Pecoits Filho, Roberto
Pereira, Marcio Antonio
Saporito, Wladmir
Scotton, Antonio Scafuto
Schuch, Tiago
de Almeida, Roberto Simoes
Ramos, Cassio Slompo
Felicio, Joao Soares
Thome, Fernando
Tibes Hachmann, Jean Carlo
Yamada, Sergio
Hayashida, Cesar Yoiti
Zanata Petry, Tarissa Beatrice
Zanella, Maria Teresa
Andreeva, Viktoria
Angelova, Angelina
Dimitrov, Stefan
Genadieva, Veselka
Genova-Hristova, Gabriela
Hristozov, Kiril
Kamenov, Zdravko
Koundurdjiev, Atanas
Lozanov, Lachezar
Margaritov, Viktor
Nonchev, Boyan
Rangelov, Rangel
Shinkov, Alexander
Temelkova, Margarita
Velichkova, Ekaterina
Yakov, Andrian
Aggarwal, Naresh
Aronson, Ronnie
Bajaj, Harpreet
Cherney, David
Chouinard, Guy
Conway, James
Cournoyer, Serge
DaRoza, Gerald
De Serres, Sacha
Dube, Francois
Goldenberg, Ronald
Gupta, Anil
Gupta, Milan
Henein, Sam
Khandwala, Hasnain
Leiter, Lawrence
Levin, Adeera
Madore, Francois
McMahon, Alan
Muirhead, Norman
Pichette, Vincent
Rabasa-Lhoret, Remi
Steele, Andrew
Tangri, Navdeep
Torshizi, Ali
Woo, Vincent
Zalunardo, Nadia
Fernandez Montenegro, Maria Alicia
Godoy Jorquera, Juan Gonzalo
Medina Farina, Marcelo
Saavedra Gajardo, Victor
Vejar, Margarita
Chen, Nan
Chen, Qinkai
Gan, Shenglian
Kong, Yaozhong
Li, Detian
Li, Wenge
Li, Xuemei
Lin, Hongli
Liu, Jian
Lu, Weiping
Mao, Hong
Ren, Yan
Song, Weihong
Sun, Jiao
Sun, Lin
Tu, Ping
Wang, Guixia
Yang, Jinkui
Yin, Aiping
Yu, Xueqing
Zhao, Minghui
Zheng, Hongguang
Accini Mendoza, Jose Luis
Arcos, Edgar
Avendano, Jorge
Diaz Ruiz, Jorge Ernesto Andres
Garcia Ortiz, Luis Hernando
Gonzalez, Alexander
Hernandez Triana, Eric
Diego Higuera, Juan
Malaver, Natalia
Ines Molina de Salazar, Dora
Rosero, Ricardo
Terront Lozano, Monica Alexandra
Valderrama Cometa, Luis
Valenzuela, Alex
Vargas Alonso, Ruben Dario
Villegas, Ivan
Yupanqui, Hernan
Bartaskova, Dagmar
Barton, Petr
Belobradkova, Jana
Dohnalova, Lenka
Drasnar, Tomas
Ferkl, Richard
Halciakova, Katarina
Klokocnikova, Vera
Kovar, Richard
Lastuvka, Jiri
Lukac, Martin
Pesickova, Satu
Peterka, Karel
Pumprla, Jiri
Rychlik, Ivan
Saudek, Frantisek
Tesar, Vladimir
Valis, Martin
Weiner, Pavel
Zemek, Stanislav
Alamartine, Eric
Borot, Sophie
Cariou, Bertrand
Dussol, Bertrand
Fauvel, Jean-Pierre
Gourdy, Pierre
Klein, Alexandre
Le Meur, Yannick
Penfornis, Alfred
Roussel, Ronan
Saulnier, Pierre-Jean
Thervet, Eric
Zaoui, Philippe
Burst, Volker
Faghih, Markus
Faulmann, Grit
Haller, Hermann
Jerwan-Keim, Reinhold
Maxeiner, Stephan
Paschen, Bjoern
Plassmann, Georg
Rose, Ludger
Gonzalez Orellana, Ronaldo Arturo
Paul Haase, Franklin
Moreira Diaz, Juan Pablo
Ramirez Roca, Luis Alberto
Sanchez Arenales, Jose Antonio
Sanchez Polo, Jose Vicente
Turcios Juarez, Erick
Csecsei, Gyongyi
Csiky, Botond
Danos, Peter
Deak, Laszlo
Dudas, Mihaly
Harcsa, Eleonora
Keltai, Katalin
Keresztesi, Sandor
Kiss, Krisztian
Konyves, Laszlo
Major, Lajos
Mileder, Margit
Molnar, Marta
Mucsi, Janos
Oroszlan, Tamas
Ory, Ivan
Paragh, Gyorgy
Peterfai, Eva
Petro, Gizella
Revesz, Katalin
Takacs, Robert
Vangel, Sandor
Vasas, Szilard
Zsom, Marianna
Abraham, Oomman
Bhushan, Raju Sree
Deepak, Dewan
Edwin, Fernando M.
Gopalakrishnan, Natarajan
Gracious, Noble
Hansraj, Alva
Jain, Dinesh
Keshavamurthy, C. B.
Khullar, Dinesh
Manisha, Sahay
Peringat, Jayameena
Prasad, Narayan
Satyanarayana, Rao K.
Sreedhar, Reddy
Sreelatha, Melemadathil
Sudhakar, Bhimavarapu
Vyasam, Ramesh Chandra
Bonadonna, Riccardo
Castellino, Pietro
Ceriello, Antonio
Chiovato, Luca
De Cosmo, Salvatore
De Nicola, Luca
Derosa, Giuseppe
Di Carlo, Alberto
Di Cianni, Graziano
Frasca, Giovanni
Fuiano, Giorgio
Gambaro, Giovanni
Garibotto, Giacomo
Giorda, Carlo
Malberti, Fabio
Mandreoli, Marcora
Mannucci, Edoardo
Orsi, Emanuela
Piatti, Piermarco
Santoro, Domenico
Sasso, Ferdinando Carlo
Serviddio, Gaetano
Stella, Andrea
Trevisan, Roberto
Veronelli, Anna Maria
Zanoli, Luca
Akiyama, Hitoshi
Aoki, Hiromi
Asano, Akimichi
Iitsuka, Tadashi
Kajiyama, Shizuo
Kashine, Susumu
Kawada, Toshio
Kodera, Takamoto
Kono, Hiroshi
Koyama, Kazunori
Kumeda, Yasuro
Miyauchi, Shozo
Mizuyama, Kazuyuki
Niiya, Tetsuji
Oishi, Hiroko
Ota, Satoshi
Sakakibara, Terue
Takai, Masahiko
Tomonaga, Osamu
Tsujimoto, Mitsuru
Wada, Takashi
Wakasugi, Masakiyo
Wakida, Yasushi
Watanabe, Takayuki
Yamada, Masayo
Yanagida, Kazuhiro
Yanase, Toshihiko
Yumita, Wataru
Gaupsiene, Egle
Kozloviene, Dalia
Navickas, Antanas
Urbanaviciene, Egle
Ghani, Rohana Abdul
Kadir, Khalid Abdul
Ali, Norsiah
Yusof, Mohd Daud Che
Gan, Chye Lee
Ismail, Mastura
Kong, Wei Yen
Lam, Swee Win
Lee, Li Yuan
Lim, Soo Kun
Loh, Chek Loong
Manocha, Anita Bhajan
Ng, Kee Sing
Ahmad, Nik Nur Fatnoon Nik
Ratnasingam, Vanassa
Bin Shudim, Saiful Shahrizal
Vengadasalam, Paranthaman
Abraira Munoz, Luis David
Alpizar Salazar, Melchor
Baas Cruz, Juan
Burgos Soto, Mario
Chevaile Ramos, Jose
Chew Wong, Alfredo
Correa Rotter, Jose Ricardo
Diaz Escalante, Tonatiu
Enriquez Sosa, Favio Edmundo
Flores Lozano, Fernando
Flota Cervera, Luis Fernando
Frenk Baron, Paul
Garcia Ballesteros, Cecilia
Gomez Rangel, Jose David
Herrera Jimenez, Luis Enrique
Irizar Santana, Sergio Saul
Jimenez Flores, Fernando
Laviada Molina, Hugo
Luna Ceballos, Rosa Isela
del Campo Blanco, Belia Martin
Morales Franco, Guadalupe
Moreno Loza, Oscar Tarsicio
Mustieles Rocha, Cynthia
Obrador Vera, Gregorio
Orozco Castellanos, Ricardo
Peralta Calcaneo, Juan
Reyes Rosano, Miguel Angel
Rodriguez Pattzi, Hiromi
Rosas Guzman, Juan
Rucker Joerg, Isabel Erika
Saavedra Sanchez, Sandra Berenice
Sanchez Mijangos, Jose Hector
Serrano Sanson, Pablo
Tamayo y Orozco, Juan Alfredo
Tellez Chavez, Eloisa
Valdes Cepeda, Alejandro
Venegas Carrillo, Luis
Villagordoa Mesa, Juan
Zamarripa Escobedo, Rolando
Baker, John
Noonan, Paul
Scott, Russell
Walker, Robert
Watson, Edward
Williams, Michael
Young, Simon
Abejuela, Zaynab
Agra, Jeimeen
Aquitania, Grace
Caringal, Clodoaido
Comia, Rhea Severina
Delos Santos, Lalaine
Gomez, Olivert
Jimeno, Cecilia
Santos, Florence
Tan, Gerry
Tolentino, Marsha
Yao, Christy
Yap, Yvette Ethel
Ygpuara, Ma. Dovie Lallaine
Bijata-Bronisz, Renata
Hotlos, Lucyna
Januszewicz, Andrzej
Kaczmarek, Barbara
Kaminska, Anna
Lazuka, Lech
Madej, Andrzej
Mazur, Stanislaw
Mlodawska-Choluj, Dorota
Nowicki, Michal
Orlowska-Kowalik, Grazyna
Popenda, Grazyna
Rewerska, Barbara
Sowinski, Dariusz
Angelescu, Liliana Monica
Anghel, Veronica
Avram, Rodica-Ioana
Busegeanu, Mihaela-Magdalena
Cif, Adriana
Cosma, Dana
Crisan, Carmen
Demian, Luiza Despina
Ferariu, Ioana Emilia
Halmagyi, Ildiko
Hancu, Nicolae
Munteanu, Mircea
Negru, Doru
Onaca, Adriana Gabriela
Petrica, Ligia
Popa, Amorin Remus
Ranetti, Aurelian-Emil
Serafinceanu, Cristian
Toarba, Cristina
Agafyina, Alina
Barbarash, Olga
Barysheva, Olga
Chizhov, Daniil
Dobronravov, Vladimir
Dreval, Alexander
Glinkina, Irina
Grineva, Elena
Khirmanov, Vladimir
Kolmakova, Elena
Koroleva, Tatiana
Kvitkova, Liudmila
Marasaev, Viacheslav
Mkrtumyan, Ashot
Morugova, Tatiana
Nagibovich, Galina
Nagibovich, Oleg
Nedogoda, Sergei
Osipova, Irina
Raskina, Tatiana
Samoylova, Yulia
Sazonova, Olga
Shamkhalova, Minara
Shutemova, Elena
Shwartz, Yuriy
Uriasyev, Oleg
Vorobyev, Sergey
Zateyshchikova, Anna
Zateyshshikov, Dmitry
Zykova, Tatyana
Antic, Slobodan
Djordjevic, Miodrag
Kendereski, Aleksandra
Lalic, Katarina
Lalic, Nebojsa
Popovic-Radinovic, Vesna
Babikova, Jana
Benusova, Olga
Buganova, Ingrid
Culak, Jan
Dzupina, Andrej
Dzuponova, Jana
Fulop, Peter
Ilavska, Adriana
Martinka, Emil
Ochodnicka, Zuzana
Pella, Daniel
Smatanova, Iveta
Ahmed, Fayzal
Badat, Aysha
Breedt, Johannes
Distiller, Lawrence
Govender, Vimladhevi
Govender, Ravendran
Joshi, Mukesh
Jurgens, Jaco
Latiff, Gulam
Lombard, Landman
Mookadam, Mohamed
Ngcakani, Nomangesi
Nortje, Hendrik
Oosthuizen, Helena
Pillay-Ramaya, Larisha
Prozesky, Hans
Reddy, Jeevren
Rheeder, Paul
Seeber, Mary
Chae, Dong-Wan
Cho, Young Min
Jeong, In-Kyung
Kim, Sin Gon
Kim, Yeong Hoon
Kwon, Hyuk-Sang
Kwon, Min Jeong
Lee, Byung-Wan
Lee, Jung Eun
Lee, Moon-Kyu
Nam, Moon-Suk
Oh, Kook-Hwan
Park, Cheol-Young
Park, Sun-Hee
Yoon, Kun Ho
Alvarez Garcia, Pere
Asmarats Mercadal, Luis
Barrios, Clara
Cereto Castro, Fernando
Cigarran Guldris, Secundino
Dominguez Lopez, Marta
Egido de los Rios, Jesus
Fernandez Fresnedo, Gema
Galan Serrano, Antonio
Garcia, Isabel
Gonzalez Martinez, Francisco Javier
Jodar Gimeno, Jose Esteban
Lopez Mendoza, Manuel
Malek Marin, Tamara
Morales Portillo, Cristobal
Munar Vila, Maria Antonia
Munoz Torres, Manuel
Nieto Iglesias, Javier
Pantoja Perez, Jonay
Perez Vera, Merce
Portoles Perez, Jose M. Y.
Quesada Simon, Maria Angustias
Simo Canonge, Rafael
Soto Gonzalez, Alfonso
Terns Riera, Manel
Tinahones Madueno, Francisco Jose
Velo Plaza, Mercedes
Chang, Chwen-Tzuei
Chuang, Lee-Ming
Hsia, Te-Lin
Hsieh, Chang-Hsun
Hwang, Shang-Jyh
Lin, Chih-Ching
Lu, Yung-Chuan
Sheu, Wayne H-H
Barna, Olga
Bilyk, Svitlana D.
Botsyurko, Volodymyr
Dudar, Iryna
Fushtey, Ivan
Godlevska, Olga
Golovchenko, Oleksandr
Gyrina, Olga
Kazmirchuk, Anatoliy
Kolesnyk, Mykola
Komisarenko, Iuliia
Korzh, Oleksii
Kravchun, Nonna
Legun, Oleg
Mankovskyy, Borys
Martynyuk, Liliya
Mostovoy, Yuriy
Pashkovska, Nataliia
Pererva, Larysa
Pertseva, Tetyana
Samoylov, Oleksandr
Smirnov, Ivan
Svyshchenko, Yevgeniya
Tomashkevych, Halyna
Topchii, Ivan
Tryshchuk, Nadiya
Tseluyko, Vira
Vizir, Vadym
Vlasenko, Maryna
Zlova, Tetiana
Zub, Liliia
Abusnana, Salah
Railey, Mohamed
Abouglila, Kamal
Ainsworth, Paul
Ali, Zishan
Arutchelvam, Vijayaraman
Barnard, Maria
Bellary, Srikanth
Davies, Emyr
Davies, Mark
Davies, Simon
Dawson, Alison
El Kossi, Mohsen
English, Patrick
Fraser, Donald
Gnudi, Luigi
Gunstone, Anthony
Hall, Timothy
Hanif, Wasim
Jackson, Alan
Johnson, Andrew
Joseph, Franklin
Krishnan, Singhan
Kumwenda, Mick
MacDougall, Iain
Nixon, Paul
O'Hare, Joseph
Philip, Sam
Ramtoola, Shenaz
Saxena, Manish
Sennik, Davesh
Simon, Godwin
Singh, Baldev
Stephens, Jeffrey
Strzelecka, Anna
Symonds, Rehan
Turner, Wayne
Wahba, Mona
Wakeling, John
Wheeler, David
Winocour, Peter
Abdallah, Joseph
Abdullah, Raied
Abramowitz, Matthew
Acosta, Idalia
Aiello, Joseph
Akright, Laura
Akyea-Djamson, Ayim
Alappan, Rajendran
Alicic, Radica
Al-Karadsheh, Amer
Allison, Dale Crawford
Arauz-Pacheco, Carlos
Arfeen, Shahabul
Arif, Ahmed
Arvind, Moogali
Atray, Naveen
Awad, Ahmed
Bakris, George
Barnhill, Peggy
Barranco, Elizabeth
Barrera, Carlos
Beacom, Matthew
Behara, Venkata
Belo, Diogo
Bentley-Lewis, Rhonda
Berenguer, Ramon
Bermudez, Lidia
Bernardo, Marializa
Biscoveanu, Mihaela
Bowman-Stroud, Cynthia
Brandon, Donald
Brusco, Osvaldo
Busch, Robert
Canaan, Yamil
Chilito, Alicia
Christensen, Tom
Christiano, Cynthia
Christofides, Elena
Chuateco, Caroucel
Cohen, Kenneth
Cohen, Robert
Cohen-Stein, Debbie
Cook, Charles
Coyne, Daniel
Daboul, Nizar
Darwish, Riad
Daswani, Adarsh
Deck, Kenneth
Desouza, Cyrus
Dev, Devasmita
Dhillon, Monika
Dua, Sohan
Eder, Frank
Elosegui, Ana Maria
El-Shahawy, Mohamed
Ervin, John
Esquenazi, Alberto
Evans, John
Fishbane, Steven
Frias, Juan
Galindo-Ramos, Eugenia
Galphin, Claude
Ghazi, Adline
Gonzalez, Enrique
Gorson, David
Gowda, Anupama
Greco, Barbara
Grubb, Stephen
Gulati, Rakesh
Hammoud, Jamal
Handelsman, Stuart
Hartman, Israel
Hershon, Kenneth
Hiser, Daniel
Hon, George
Jacob, Radu
Jaime, Maria
Jamal, Aamir
Kaupke, Charles
Keightley, Gerald
Kern, Elizabeth
Khanna, Rakhi
Khitan, Zeid
Kim, Sun
Kopyt, Nelson
Kovesdy, Csaba
Krishna, Gopal
(Jay) Kropp, Jeffrey
Kumar, Amrendra
Kumar, Jayant
Kumar, Neil
Kusnir, Jorge
Lane, Wendy
Lawrence, Mary
Lehrner, Lawrence
Lentz, John
Levinson, Dennis
Lewis, Derek
Liss, Kenneth
Maddux, Andreas
Maheshwari, Hiralal
Mandayam, Sreedhar
Marar, Isam
Mehta, Bhasker
Middleton, John
Mordujovich, Jorge
Moreda, Ramon
Moustafa, Moustafa
Trenche, Samuel Mujica
Narayanan, Mohanram
Narvarte, Javier
Nassar, Tareq
Newman, George
Nichol, Brian
Nicol, Philip
Nisnisan, Josier
Nossuli, A. Kaldun
Obialo, Chamberlain
Olelewe, Sarah
Oliver, Michael
O'Shaughnessy, Andrew
Padron, John
Pankhaniya, Rohit
Parker, Reginald
Patel, Devesh
Patel, Gnyandev
Patel, Nina
Pavon, Humberto
Perez, Armando
Perez, Carlos
Perlman, Alan
Pettis, Karlton
Pharr, Walter
Phillips, Andrea
Purighalla, Raman
Quesada-Suarez, Luis
Ranjan, Rajiv
Rastogi, Sanjeev
Reddy, Jakkidi
Rendell, Marc
Rich, Lisa
Robinson, Michael
Rodriguez, Hector
Rosas, Sylvia
Saba, Fadi
Sankaram, Rallabhandi
Sarin, Ravi
Schreiman, Robert
Scott, David
Sekkarie, Mohamed
Sensenbrenner, John
Shakeel, Muhammad
Shanik, Michael
Shaw, Sylvia
Smith, Stephen
Solomon, Richard
Sprague, Amy
Spry, Leslie
Suchinda, Pusadee
Sultan, Senan
Surampudi, Prasanth
Sussman, Sherry
Tan, Anjanette
Terrelonge, Antonio
Thompson, Michael
Trespalacios, Fernando
Trippe, Bruce
Trueba, Pilar
Twahirwa, Marcel
Updegrove, John
Van Buren, Peter
Vannorsdall, Mark
Varghese, Freemu
Velasquez-Mieyer, Pedro
Ventrapragada, Sailaja
Vukotic, Goga
Wadud, Khurram
Warren, Mark
Watson, Henry
Watts, Ronald
Weiner, Daniel
Welker, James
Welsh, Jean
Williams, Shelley
Zaniewski-Singh, Michelle
AffiliationStanford Univ, Sch Med, Stanford Ctr Clin Res Dept Med, 300 Pasteur Dr,Grant S-102, Stanford, CA 94305 USA
Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia
Concord Repatriat Gen Hosp, Sydney, NSW, Australia
Brigham & Womens Hosp, Cardiovasc Div, 75 Francis St, Boston, MA 02115 USA
Univ Sydney, Charles Perkins Ctr, Sydney, NSW, Australia
Imperial Coll London, London, England
Univ Groningen, Univ Med Ctr Groningen, Dept Clin Pharm & Pharmacol, Groningen, Netherlands
NYU Sch Med, Nephrol Div, New York, NY USA
NYU Langone Med Ctr, New York, NY USA
Baim Inst Clin Res, Boston, MA USA
Janssen Res & Dev LLC, Raritan, NJ USA
Indiana Univ Sch Med, Indianapolis, IN 46202 USA
VA Med Ctr, Indianapolis, IN 46202 USA
Univ Chicago Med, Dept Med, Chicago, IL USA
Univ Utah, Div Biostat, Dept Populat Hlth Sci, Salt Lake City, UT USA
Univ British Columbia, Div Nephrol, Vancouver, BC, Canada
Univ Sydney, Royal North Shore Hosp, Sydney Med Sch, Kolling Inst Med Res, St Leonards, NSW, Australia
UCL Med Sch, Dept Renal Med, London, England
Peking Univ, Hosp 1, Renal Div, Beijing, Peoples R China
Univ Toronto, Mt Sinai Hosp, Lunenfeld Tanenbaum Res Insti, Toronto, ON, Canada
Harvard Med Sch, Brigham & Womens Hosp, Renal Div, Boston, MA 02115 USA
Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA
Royal North Shore Hosp, Sydney, NSW, Australia
Keywordscanagliflozin
clinical trial
diabetes mellitus
primary prevention
renal insufficiency
chronic
secondary prevention
Issue Date2019
PublisherCIRCULATION
AbstractBackground: Canagliflozin reduces the risk of kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease, but effects on specific cardiovascular outcomes are uncertain, as are effects in people without previous cardiovascular disease (primary prevention). Methods: In CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation), 4401 participants with type 2 diabetes mellitus and chronic kidney disease were randomly assigned to canagliflozin or placebo on a background of optimized standard of care. Results: Primary prevention participants (n=2181, 49.6%) were younger (61 versus 65 years), were more often female (37% versus 31%), and had shorter duration of diabetes mellitus (15 years versus 16 years) compared with secondary prevention participants (n=2220, 50.4%). Canagliflozin reduced the risk of major cardiovascular events overall (hazard ratio [HR], 0.80 [95% CI, 0.67-0.95]; P=0.01), with consistent reductions in both the primary (HR, 0.68 [95% CI, 0.49-0.94]) and secondary (HR, 0.85 [95% CI, 0.69-1.06]) prevention groups (P for interaction=0.25). Effects were also similar for the components of the composite including cardiovascular death (HR, 0.78 [95% CI, 0.61-1.00]), nonfatal myocardial infarction (HR, 0.81 [95% CI, 0.59-1.10]), and nonfatal stroke (HR, 0.80 [95% CI, 0.56-1.15]). The risk of the primary composite renal outcome and the composite of cardiovascular death or hospitalization for heart failure were also consistently reduced in both the primary and secondary prevention groups (P for interaction >0.5 for each outcome). Conclusions: Canagliflozin significantly reduced major cardiovascular events and kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease, including in participants who did not have previous cardiovascular disease.
URIhttp://hdl.handle.net/20.500.11897/545732
ISSN0009-7322
DOI10.1161/CIRCULATIONAHA.119.042007
IndexedSCI(E)
Appears in Collections:第一医院

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