TitleAberrant Expression of Histamine-independent Pruritogenic Mediators in Keratinocytes may be Involved in the Pathogenesis of Prurigo Nodularis
AuthorsZhong, Weilong
Wu, Xia
Zhang, Wei
Zhang, Jie
Chen, Xiaofan
Chen, Shihong
Huang, Haiyan
Yang, Yong
Yu, Bo
Dou, Xia
AffiliationPeking Univ, Hosp 1, Dept Dermatol, Beijing 100034, Peoples R China
Peking Univ, Shenzhen Hosp, Dept Dermatol, Shenzhen 518036, Guangdong, Peoples R China
Hong Kong Univ Sci & Technol, Med Ctr, Shenzhen Peking Univ, Shenzhen Key Lab Translat Med Dermatol, Shenzhen, Guangdong, Peoples R China
Keywordsprurigo nodularis
pruritogenic mediator
nerve growth factor
Issue Date2019
AbstractPrurigo nodularis is a highly pruritic and hyperplastic chronic dermatosis with unknown pathogenesis. Many pruritogenic mediators, including nerve growth factor, interleukin (IL)-31, thymic stromal lymphopoietin, and endothelin-1, are implicated in chronic itch and inflammation. This study investigated the mRNA levels and immunoreactivity of the nerve growth factor, IL-31, thymic stromal lymphopoietin, and endothelin axes in both lesional and perilesional skin in prurigo nodularis by using quantitative real-time PCR and immunohistochemistry studies. The nerve growth factor high-affinity receptor tyrosine kinase receptor A was upregulated while the low affinity receptor p75 neurotrophin receptor was downregulated in prurigo nodularis lesions. Downregulated expression of IL-31/IL-31 receptor A and endothelin-3/endothelin receptor B and upregulation of thymic stromal lymphopoietin receptor were found in prurigo nodularis lesions. Aberrant expression of nerve growth factor, IL-31, endothelin, and thymic stromal lymphopoietin axes was found in prurigo nodularis lesions, especially in the epidermis, indicating the importance of keratinocytes in prurigo nodularis pathogenesis.
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