TitleF-18-FDG PET/CT in diagnosis and staging of tongue squamous cell carcinoma
AuthorsZheng, Dong
Niu, Lixuan
Fei, Jun
Li, Ke
Tian, Jiahe
AffiliationGen Hosp PLA, Dept Nucl Med, 28 Fuxing Rd, Beijing 100853, Peoples R China
306 Hosp PLA, Dept Radiol, Beijing, Peoples R China
Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Beijing, Peoples R China
KeywordsTongue squamous cell carcinoma
positron-emission tomography and computed tomography
Issue Date2019
AbstractThe aim of the present study was to evaluate the application value of F-18-fluorodeoxyglucose (F-18-FDG) PET/CT in the diagnosis and staging of tongue squamous cell carcinoma. In 52 patients with tongue squamous cell carcinoma confirmed by pathology, there were 34 males and 18 females (age, 22-78 years; mean age, 52.2 years). F-18-FDG PET/CT manifestations of the 52 patients were retrospectively analyzed; TNM staging and histopathological differentiation grading of the 52 patients were assessed according to postoperative pathology, and associations between 18F-FDG uptake and differentiation or staging of tongue squamous cell carcinoma were examined. Preoperative staging was prospectively reviewed and the results were compared with those of postoperative pathological staging. The results showed that the majority of patients were at middle or advanced stage (28/52) when newly diagnosed. The lesions were mostly located in the middle or middle-posterior part of the tongue (38/52). The sensitivity of PET/CT in diagnosing tongue squamous cell carcinoma was 92.3%. There were no statistically significant differences in the maximum Standardized Uptake Value (SUVmax) in the well, moderate-well and moderate degree of tongue carcinoma cell differentiation (P = 0.109). The SUVmax in stage III or IV patients was statistically significantly higher than that in stage I or II (P = 0.000). There was an excellent correlation between the result of preoperative PET/CT and postoperative pathological staging (Kappa = 0.859, P = 0.000). The accuracy of PET/CT in staging tongue squamous cell carcinoma was 90.4% (47/52). Conclusions can be drawn that the SUVmax correlates well with the stage of the tongue squamous cell carcinoma but not with the degree of de-differentiation. FDG PET/CT is highly sensitive for the diagnosis and highly accurate for pre-surgical staging of tongue squamous cell carcinoma and is a highly accurate noninvasive imaging approach for the pre-surgical diagnosis and staging.
Appears in Collections:口腔医院

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