| Title | A potential role for the CDH13/CDH15 gene in repeat revascularization after first percutaneous coronary intervention |
| Authors | Xiang, Qian Liu, Zhiyan Lu, Yun Mao, Jie Chen, Shuqing Zhao, Xun Zhou, Shuang Xie, Qiufen Wang, Zining Mu, Guangyan Jiang, Jie Gong, Yanjun Cui, Yimin |
| Affiliation | Peking Univ, Hosp 1, Dept Pharm, 6 Da Hong Luo Chang St, Beijing 100034, Peoples R China Hennepin Cty Med Ctr, Dept Pharm, 701 Pk Ave, Minneapolis, MN 55415 USA Gennlife Beijing Technol Co Ltd, 65 North Fourth Ring Rd West, Beijing 100080, Peoples R China Peking Univ, Dept Cardiol, Hosp 1, 8 Xi Shi Ku Da Jie St, Beijing 100034, Peoples R China |
| Keywords | GENOME-WIDE ASSOCIATION T-CADHERIN RESTENOSIS ADIPONECTIN CDH13 RISK POLYMORPHISMS METAANALYSIS PROMOTER LOCUS |
| Issue Date | Jan-2020 |
| Publisher | PHARMACOGENOMICS |
| Abstract | Aim: Major drawbacks of percutaneous coronary intervention are the high occurrence of repeat revascularization due to restenosis and disease progression. The aim of this study was to find genetic indicators to predict the risk of repeat revascularization. Materials & methods: From April 2015 to June 2016, 143 patients with percutaneous coronary intervention with genetic test results were enrolled. SNPs were measured by OmniZhongHua-8, and the SNPs in pathways genes related to known stenosis-related processes from the KEGG, BioCarta and Gene Cards databases were selected for analysis. Results: Cell-extracellular matrix interactions were the pathways with the most significant SNP (CDH15 rs72819363) association with repeat revascularization. Compared with CDH13 rs11859453G carriers, the adjusted odds ratio for A carriers was 0.25 and 0.33 at 18 and 30 months. Conclusion: We demonstrated a potential role of the cell-extracellular matrix interactions pathway and the possible biomarker CDH13/CDH15 in the development of coronary repeat revascularization. |
| URI | http://hdl.handle.net/20.500.11897/586095 |
| ISSN | 1462-2416 |
| DOI | 10.2217/pgs-2019-0118 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 |
