TitleAnti-FXa-lla activity test in Asian and its potential role for drug adherence evaluation in patients with direct oral anticoagulants: a nationwide multi-center synchronization study
AuthorsLiu, Zhiyan
Xie, Qiufen
Xiang, Qian
Zhang, Hanxu
Mu, Guangyan
Zhao, Zinan
Hu, Taotao
Wu, Tingting
Wang, Na
Zhang, Jinhua
Qian, Yan
Zhou, Shuang
Wang, Zining
Jiang, Jie
Zhang, Yatong
Song, Hongtao
Cui, Yimin
AffiliationPeking Univ First Hosp, Dept Pharm, 6 Dahongluochang St, Beijing 100034, Peoples R China
Peking Univ, Sch Pharmaceut Sci, Hlth Sci Ctr, Beijing, Peoples R China
Beijing Hosp, Dept Pharm, Beijing, Peoples R China
900 Hosp Joint Logist Team, Dept Pharm, Fuzhou, Peoples R China
Fujian Med Univ, Union Hosp, Dept Pharm, Fuzhou, Peoples R China
Chongqing Med Univ, Affiliated Hosp 2, Dept Pharm, Chongqing, Peoples R China
Peking Univ First Hosp, Dept Cardiol, Beijing, Peoples R China
KeywordsNONVALVULAR ATRIAL-FIBRILLATION
MEDICATION ADHERENCE
COAGULATION ASSAYS
DABIGATRAN
RIVAROXABAN
WARFARIN
ASSOCIATION
PERSISTENCE
MANAGEMENT
Issue DateOct-2020
PublisherCARDIOVASCULAR DIAGNOSIS AND THERAPY
AbstractBackground: The data of anti-FXa-IIa activity detection in Asian population is insufficient, and its potential role for drug adherence evaluation in patients with direct oral anticoagulants (DOACs) remains unclear. This study carried out multi-center anti-FXa-IIa activity detection in Asian, aiming to explore its applicability in Asian population and find its role in adherence evaluation. Methods: We assessed patients' self-reported adherence using the Morisky, Green, and Levine Adherence Scale (MGLS) from six hospitals. Plasma samples were collected for peak and trough concentration determination, and anti-FXa-lia chromogenic assay was conducted using rivaroxaban/dabigatran calibrators and controls. Multivariate logistic regression models, covariate adjustment and spearman's two-tailed test were conducted in the data analysis. This study had been registered in clinical trials (NCT03666962). Results: In total, 271 patients taking rivaroxaban (n=149) or dabigatran (n=122) were enrolled. Among the 271 patients assessed by MGLS questionnaire, 188 persons (69.4%) showed high adherence, 77 persons (28.4%) was in intermediate adherence group, and only 6 patients (2.2%) had low adherence. Patients are more adherent dosed once daily of rivaroxaban compared to twice daily of dabigatran: 75.6% vs. 63.6%. Anti-FXa-IIa activity had good linear correlation with routine coagulation indexes (P<0.001), but no significant association was found between drug adherence and anti-FXa-IIa activity (P>0.05). Conclusions: This study confirms that anti-FXa-IIa activity detection based on target drug calibrations can be used as an effective index for pharmacodynamic evaluation in Asian population, but had limited value in drug adherence evaluation for DOACs. As the limited samples, these findings could serve as a hypothesis-generating effort, and should be validated in further studies with larger sample sizes.
URIhttp://hdl.handle.net/20.500.11897/599182
ISSN2223-3652
DOI10.21037/cdt-20-564
IndexedSCI(E)
Appears in Collections:第一医院
药学院

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