TitleValidation of nomogram-revised risk index and comparison with other models for extranodal nasal-type NK/T-cell lymphoma in the modern chemotherapy era: indication for prognostication and clinical decision-making
AuthorsChen, Si-Ye
Yang, Yong
Qi, Shu-Nan
Wang, Ying
Hu, Chen
He, Xia
Zhang, Li-Ling
Wu, Gang
Qu, Bao-Lin
Qian, Li-Ting
Hou, Xiao-Rong
Zhang, Fu-Quan
Qiao, Xue-Ying
Wang, Hua
Li, Gao-Feng
Zhang, Yu-Jing
Zhu, Yuan
Cao, Jian-Zhong
Lan, Sheng-Min
Wu, Jun-Xin
Wu, Tao
Zhu, Su-Yu
Shi, Mei
Xu, Li-Ming
Yuan, Zhi-Yong
Yahalom, Joachim
Tsang, Richard
Song, Yu-Qin
Zhu, Jun
Su, Hang
Li, Ye-Xiong
AffiliationChinese Acad Med Sci CAMS, Natl Canc Ctr, Natl Clin Res Ctr Canc, Canc Hosp, Beijing, Peoples R China
Peking Union Med Coll PUMC, Beijing, Peoples R China
Chongqing Univ, Canc Hosp, Chongqing, Peoples R China
Chongqing Canc Hosp, Chongqing, Peoples R China
Johns Hopkins Univ, Div Biostat & Bioinformat, Sidney Kimmel Comprehens Canc Ctr, Sch Med, Baltimore, MD 21205 USA
Jiangsu Canc Hosp, Nanjing, Jiangsu, Peoples R China
Jiangsu Inst Canc Res, Nanjing, Jiangsu, Peoples R China
Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Wuhan, Hubei, Peoples R China
Chinese Peoples Liberat Army, Gen Hosp, Beijing, Peoples R China
Anhui Med Univ, Affiliated Prov Hosp, Hefei, Anhui, Peoples R China
Chinese Acad Med Sci CAMS, Peking Union Med Coll Hosp, Beijing, Peoples R China
Hebei Med Univ, Hosp 4, Shijiazhuang, Hebei, Peoples R China
Nanchang Univ, Affiliated Hosp 2, Nanchang, Jiangxi, Peoples R China
Beijing Hosp, Natl Geriatr Med Ctr, Beijing, Peoples R China
Sun Yat Sen Univ, Canc Ctr, State Key Lab Oncol South China, Guangzhou, Peoples R China
Collaborat Innovat Ctr Canc Med, Guangzhou, Peoples R China
Zhejiang Canc Hosp, Hangzhou, Zhejiang, Peoples R China
Shanxi Med Univ, Shanxi Canc Hosp, Taiyuan, Shanxi, Peoples R China
Shanxi Med Univ, Affiliated Canc Hosp, Taiyuan, Shanxi, Peoples R China
Fujian Prov Canc Hosp, Fuzhou, Fujian, Peoples R China
Guizhou Med Univ, Guizhou Canc Hosp, Affiliated Hosp, Guiyang, Guizhou, Peoples R China
Hunan Canc Hosp, Changsha, Hunan, Peoples R China
Xiangya Sch Med, Affiliated Canc Hosp, Changsha, Hunan, Peoples R China
Fourth Mil Med Univ, Xijing Hosp, Xian, Peoples R China
Tianjin Med Univ, Canc Inst & Hosp, Key Lab Canc Prevent & Therapy, Natl Clin Res Ctr Canc, Tianjin, Peoples R China
Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA
Univ Toronto, Univ Hlth Network, Princess Margaret Hosp, Toronto, ON, Canada
Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing, Peoples R China
Peoples Liberat Army Gen Hosp, Med Ctr 5, Beijing, Peoples R China
Issue DateMar-2020
AbstractDerived from our original nomogram study by using the risk variables from multivariable analyses in the derivation cohort of 1383 patients with extranodal NK/T-cell lymphoma, nasal-type (ENKTCL) who were mostly treated with anthracycline-based chemotherapy, we propose an easily used nomogram-revised risk index (NRI), validated it and compared with Ann Arbor staging, the International Prognostic Index (IPI), Korean Prognostic Index (KPI), and prognostic index of natural killer lymphoma (PINK) for overall survival (OS) prediction by examining calibration, discrimination, and decision curve analysis in a validation cohort of 1582 patients primarily treated with non-anthracycline-based chemotherapy. The calibration of the NRI showed satisfactory for predicting 3- and 5-year OS in the validation cohort. The Harrell's C-index and integrated Brier score (IBS) of the NRI for OS prediction demonstrated a better performance than that of the Ann Arbor staging system, IPI, KPI, and PINK. Decision curve analysis of the NRI also showed a superior outcome. The NRI is a promising tool for stratifying patients with ENKTCL into risk groups for designing clinical trials and for selecting appropriate individualized treatment.
Appears in Collections:北京肿瘤医院

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