TitleF-18-Boramino acid PET/CT in healthy volunteers and glioma patients
AuthorsLi, Zhu
Kong, Ziren
Chen, Junyi
Li, Jiyuan
Li, Nan
Yang, Zhi
Wang, Yu
Liu, Zhibo
AffiliationPeking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing,Dept Nucl Med, Beijing 100871, Peoples R China
Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurosurg, Beijing, Peoples R China
Peking Univ, Radiochem & Radiat Chem Key Lab Fundamental Sci, Beijing Natl Lab Mol Sci, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
Tsinghua Univ, Peking Univ, Ctr Life Sci, Beijing 100871, Peoples R China
Issue DateFeb-2021
PublisherEUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
AbstractPurpose In this work, the safety, biodistribution, and radiation dosimetry of large neutral amino acid transporter type-1 (LAT-1) targeting PET tracer F-18-trifluorobborate-derived tyrosine (denoted as F-18-FBY) has been investigated. It is designed as a first-in-human study in healthy volunteers and to assay LAT-1 expression level in glioma patients. Methods Six healthy volunteers (3 M, 3 F) underwent whole-body PET acquisitions at multiple time points after bolus injection of F-18-FBY. Regions of interest (ROIs) were mapped manually on major organs, and then the time-activity curves (TACs) were obtained. Dosimetry was calculated with the OLINDA/EXM software. Thirteen patients who were suspected of glioma were scanned with PET/CT at 30 min after F-18-FBY injection. Within 7 days after PET/CT, the tumor was removed surgically, and LAT-1 immunohistochemical staining for LAT-1 was performed on tumor samples and correlated with F-18-FBY PET imaging. Results F-18-FBY was well tolerated by all healthy volunteers, and no adverse symptoms were observed or reported. F-18-FBY is rapidly cleared from the blood circulation and excreted mainly through the kidneys and urinary tract. The effective dose (ED) was 0.0039 +/- 0.0006 mSv/MBq. In 14 surgical confirmed gliomas (one of the patiens had two gliomas), F-18-FBY uptake increased consistently with tumor grade, with maximum standard uptake values (SUVmax) of 0.28 +/- 0.14 and 2.84 +/- 0.46 and tumor-to-normal contralateral activity (T/N) ratio of 2.30 +/- 1.26 and 24.56 +/- 6.32 in low- and high-grade tumors, respectively. In addition to the significant difference in the uptakes between low- and high-grade gliomas (P < 0.001), the immunohistochemical staining confirmed the positive correlations between the SUVmax, LAT-1 expression (r(2) = 0.80, P < 0.001), and Ki-67 labeling index (r(2) = 0.79, P < 0.001). Conclusion F-18-FBY is a PET tracer with favorable dosimetry profile and pharmacokinetics. It has the potential to assay LAT-1 expression in glioma patients and may provide imaging guidance for further boron neutron capture therapy of gliomas.
URIhttp://hdl.handle.net/20.500.11897/608565
ISSN1619-7070
DOI10.1007/s00259-021-05212-7
IndexedSCI(E)
Appears in Collections:北京肿瘤医院
化学与分子工程学院
生命科学学院

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