| Title | PNPT1 and PCGF3 variants associated with angiotensin-converting enzyme inhibitor-induced cough: a nested case-control genome-wide study |
| Authors | Mu, Guangyan Xiang, Qian Zhang, Zhuo Liu, Chengzhang Zhang, Hanxu Liu, Zhiyan Pang, Xiaocong Jiang, Jie Xie, Qiufen Zhou, Shuang Wang, Zining Hu, Kun Wang, Zhe Jiang, Shanqun Qin, Xianhui Cui, Yimin |
| Affiliation | Peking Univ First Hosp, Dept Pharm, Beijing 100034, Peoples R China Shenzhen Evergreen Med Inst, Res Ctr, Shenzhen 518057, Peoples R China Peking Univ First Hosp, Dept Cardiol, Beijing 100034, Peoples R China Anhui Univ, Sch Life Sci, Hefei 230601, Peoples R China Southern Med Univ, Nanfang Hosp, Div Nephrol, Guangzhou 510515, Peoples R China |
| Keywords | ENALAPRIL-INDUCED COUGH GENE POLYMORPHISM READ ALIGNMENT RECEPTOR GENE B2 RECEPTOR IDENTIFICATION EXPRESSION SUSCEPTIBILITY HYPERTENSION DISCOVERY |
| Issue Date | Jun-2020 |
| Publisher | PHARMACOGENOMICS |
| Abstract | Aim: We aimed to identify genetic variants associated with ACE inhibitor (ACEI)-induced cough. Materials & methods: A nested case-control study was performed among hypertensive Chinese patients receiving enalapril-only therapy. Whole-exome sequencing and genome-wide association analysis were performed. Results: We identified that PNPT1 rs13015243 (odds ratio [OR]: 0.47; 95% CI: 0.34-0.66; p = 7.45 x 10(-6)), PNPT1 rs13009649 (OR: 0.48; 95% CI: 0.35-0.67; p = 9.96 x 10(-6)) and PCGF3 rs1044147 (OR: 2.67; 95% CI: 1.71-4.17; p = 9.91 x 10(-6)) were significantly associated with ACEI-induced cough. Nearly genome-wide significant associations in previously reported candidate risk genes CLASP1, ACE, CES1, CPN1, XPNPEP1, PDE11A or SLC38A were detected in our dataset. Conclusion: Our results suggest that ACEI-induced cough is associated with noncoding SNPs of PNPT1 and PCGF3, all of which are independent of the bradykinin pathway. |
| URI | http://hdl.handle.net/20.500.11897/621526 |
| ISSN | 1462-2416 |
| DOI | 10.2217/pgs-2019-0167 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 |
