TitleArterial Labeling Ultrasound Subtraction Angiography (ALUSA) Based on Acoustic Phase-Change Nanodroplets
AuthorsAn, Jian
Zhang, Jiabin
Dong, Feihong
Yin, Jingyi
Feng, Feng
Guo, Wenyu
Huang, Shuo
Wang, Di
Dang, Jie
Zhang, Jue
Cheng, Heping
AffiliationPeking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
Peking Univ, State Key Lab Membrane Biol, Beijing Key Lab Cardiometab Mol Med, Peking Tsinghua Ctr Life Sci,Coll Future Technol, Beijing 100871, Peoples R China
Peking Univ, Coll Engn, Beijing 100871, Peoples R China
Peking Univ, Natl Biomed Imaging Ctr, Beijing 100871, Peoples R China
Chinese Acad Med Sci, PKU Nanjing Inst Translat Med, Res Unit Mitochondria Brain Dis, Nanjing 210031, Peoples R China
KeywordsCONTRAST-ENHANCED ULTRASOUND
RENAL PERFUSION
IN-VIVO
AGENTS
MICROCIRCULATION
KINETICS
MRI
Issue DateJan-2022
PublisherSMALL
AbstractBiomedical imaging technology (like digital subtraction angiography (DSA)) based on contrast agents has been widely employed in the diagnosis of vascular-related diseases. While the DSA achieves the high-resolution observation of specified vessels and their downstream perfusion at the cost of invasive, radioactive operation and hepatorenal toxicity. To address those problems, this study develops arterial labeling ultrasound (US) subtraction angiography (ALUSA) based on a new perfluorobutane (PFB) nanodroplets with a lower vaporization threshold through spontaneous nucleation. The nanodroplets can be selectively vaporized to microbubbles, indicating a highly echogenic signal at B-mode images only using a diagnostic transducer. By labeling a single blood vessel for nanodroplets vaporization and tracking its downstream blood perfusion in segmental renal arteries at a frame rate of 500 Hz. The results demonstrate the color-coded super-resolution ALUSA image, exhibiting the downstream arcuate and interlobular arteries of each segmental renal artery with a resolution of 36 mu m in a rabbit kidney. Furthermore, ALUSA could offer the vascular structures, blood flow velocity, and direction of their primary supply vessels in the mouse breast tumor. ALUSA fills the gap of noninvasive labeling angiography in US and opens a broad vista in the diagnosis and treatment of tumor and vascular-related diseases.
URIhttp://hdl.handle.net/20.500.11897/637319
ISSN1613-6810
DOI10.1002/smll.202105989
IndexedEI
SCI(E)
Appears in Collections:前沿交叉学科研究院
生命科学学院
膜生物学国家重点实验室
工学院

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