TitlePerceptual spatial position induces the attentional enhancement of prepulse inhibition and its neural mechanism
AuthorsChen, Langjie
Liu, Lei
Ge, Zhongshu
Yang, Xiaodong
Yang, Pengcheng
Li, Liang
AffiliationPeking Univ, Sch Psychol & Cognit Sci, Beijing Key Lab Behav & Mental Hlth, Beijing 100080, Peoples R China
Peking Univ, Minist Educ, Speech & Hearing Res Ctr, Key Lab Machine Percept, Beijing 100871, Peoples R China
KeywordsCONDITIONING-INDUCED ENHANCEMENT
MEDIAL AGRANULAR CORTEX
DORSOCENTRAL STRIATUM
STARTLE RESPONSE
ASSOCIATIVE STRIATUM
ONE EAR
FEAR
REFLEX
SCHIZOPHRENIA
PROJECTIONS
Issue DateJul-2022
PublisherHEARING RESEARCH
AbstractPrepulse inhibition (PPI) is a sensorimotor gating process that reduces the startling response when a weaker sensory stimulus precedes a sudden startling stimulus. Perceptual spatial separation (PSS) be-tween the prepulse and the background noise was found to enhance PPI compared to perceptual spatial co-location (PSC). However, little is known about the perceptual characteristics of prepulses in the PSS that induce more inhibition of the startling response and the associated neural mechanism. The dorsocen-tral striatum (DCS) was the convergence of spatial information from the cortical and thalamic circuits. Our study investigated whether the perceptual spatial position of prepulses induced spatial attentional modu-lation of PPI. In addition, whether the DCS was involved in spatial attentional modulation's neural circuits of PPI. In our study, the relative perceptual image positions of the prepulse and masker were controlled by the playback time difference between the two loudspeakers, i.e., PSS and PSC. The specific spatial attention of the prepulse was conditioned by foot shock. The results revealed that PPI was generally en-hanced after fear conditioning/conditioning-control manipulation across all rats. Further enhancement of PPI in the PSS condition occurred only in the fear conditioning position, not in the conditioning-control position. We first found that PPI did not show specific spatial enhancement in the drug-blocking bilat-eral DCS rats with 2 mM kynurenic acid. These results demonstrated that the perceptual spatial position modulated the spatial attention of prepulse and improved PPI. DCS was involved in the attentional mod-ulation neural circuits of PPI and processed spatial information of prepulse.(c) 2022 Elsevier B.V. All rights reserved.
URIhttp://hdl.handle.net/20.500.11897/648047
ISSN0378-5955
DOI10.1016/j.heares.2022.108511
IndexedSCI(E)
Appears in Collections:心理与认知科学学院
行为与心理健康北京市重点实验室
信息科学技术学院
机器感知与智能教育部重点实验室

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