TitleA Molecular Logic Gate for Developing "AND" Logic Probes and the Application in Hepatopathy Differentiation
AuthorsChen, Mengqi
Wang, Chunhong
Ding, Zexuan
Wang, Hao
Wang, Yu
Li, Zhibo
AffiliationPeking Univ, Coll Chem & Mol Engn, Minist Educ,Beijing Natl Lab Mol Sci,Radiochem &, Key Lab Bioorgan Chem & Mol Engn,NMPA Key Lab Res, Beijing 100871, Peoples R China
Peking Univ Third Hosp, Dept Radiat Oncol, Beijing 100191, Peoples R China
Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurosurg, Beijing 100730, Peoples R China
KeywordsLEUCINE AMINOPEPTIDASE
FLUORESCENT-PROBES
CHEMISTRY
CANCER
Issue Date22-Jun-2022
PublisherACS CENTRAL SCIENCE
AbstractAccurate diagnosis and therapy are challenging because most diseases lack a single biomarker that distinguishes them from other disorders. A solution would enhance targeting accuracy by using AND-gated combinations of two diseaseassociated stimuli. Here, we report a novel "AND" molecular logic gate, enabling a double-controlled release of intact functional molecules. Benefiting from a significant difference in intrawith the presence of both stimuli. According to this finding, several AND logic probes have been developed that respond to a broad scope of stimuli and show remarkably improved signal-tobackground contrast compared to those of monoresponsive probes. In addition, an AND logic probe that is responsive to monoamine oxidase (MAO) and leucine aminopeptidase (LAP) has been constructed for hepatopathy diagnosis. It works efficiently in living cells and mouse models. Of note, this probe can successfully differentiate cirrhotic from hepatitis B by testing the blood samples from patients.
URIhttp://hdl.handle.net/20.500.11897/648270
ISSN2374-7943
DOI10.1021/acscentsci.2c00387
IndexedSCI(E)
Appears in Collections:化学与分子工程学院
生物有机与分子工程教育部重点实验室
第三医院

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