TitleA multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
AuthorsRamdas, Shweta
Judd, Jonathan
Graham, Sarah E.
Kanoni, Stavroula
Wang, Yuxuan
Surakka, Ida
Wenz, Brandon
Clarke, Shoa L.
Chesi, Alessandra
Wells, Andrew
Bhatti, Konain Fatima
Vedantam, Sailaja
Winkler, Thomas W.
Locke, Adam E.
Marouli, Eirini
Zajac, Greg J. M.
Wu, Kuan-Han H.
Ntalla, Ioanna
Hui, Qin
Klarin, Derek
Hilliard, Austin T.
Wang, Zeyuan
Xue, Chao
Thorleifsson, Gudmar
Helgadottir, Anna
Gudbjartsson, Daniel F.
Holm, Hilma
Olafsson, Isleifur
Hwang, Mi Yeong
Han, Sohee
Akiyama, Masato
Sakaue, Saori
Terao, Chikashi
Kanai, Masahiro
Zhou, Wei
Brumpton, Ben M.
Rasheed, Humaira
Havulinna, Aki S.
Veturi, Yogasudha
Pacheco, Jennifer Allen
Rosenthal, Elisabeth A.
Lingren, Todd
Feng, QiPing
Kullo, Iftikhar J.
Narita, Akira
Takayama, Jun
Martin, Hilary C.
Hunt, Karen A.
Trivedi, Bhavi
Haessler, Jeffrey
Giulianini, Franco
Bradford, Yuki
Miller, Jason E.
Campbell, Archie
Lin, Kuang
Millwood, Iona Y.
Rasheed, Asif
Hindy, George
Faul, Jessica D.
Zhao, Wei
Weir, David R.
Turman, Constance
Huang, Hongyan
Graff, Mariaelisa
Choudhury, Ananyo
Sengupta, Dhriti
Mahajan, Anubha
Brown, Michael R.
Zhang, Weihua
Yu, Ketian
Schmidt, Ellen M.
Pandit, Anita
Gustafsson, Stefan
Yin, Xianyong
Luan, Jian'an
Zhao, Jing-Hua
Matsuda, Fumihiko
Jang, Hye-Mi
Yoon, Kyungheon
Medina-Gomez, Carolina
Pitsillides, Achilleas
Hottenga, Jouke Jan
Wood, Andrew R.
Ji, Yingji
Gao, Zishan
Haworth, Simon
Mitchell, Ruth E.
Chai, Jin Fang
Aadahl, Mette
Bjerregaard, Anne A.
Yao, Jie
Manichaikul, Ani
Lee, Wen-Jane
Hsiung, Chao Agnes
Warren, Helen R.
Ramirez, Julia
Bork-Jensen, Jette
Karhus, Line L.
Goel, Anuj
Sabater-Lleal, Maria
Noordam, Raymond
Mauro, Pala
Matteo, Floris
McDaid, Aaron F.
Marques-Vidal, Pedro
Wielscher, Matthias
Trompet, Stella
Sattar, Naveed
Mollehave, Line T.
Munz, Matthias
Zeng, Lingyao
Huang, Jianfeng
Yang, Bin
Poveda, Alaitz
Kurbasic, Azra
Schonherr, Sebastian
Forer, Lukas
Scholz, Markus
Galesloot, Tessel E.
Bradfield, Jonathan P.
Ruotsalainen, Sanni E.
Daw, E. Warwick
Zmuda, Joseph M.
Mitchell, Jonathan S.
Fuchsberger, Christian
Christensen, Henry
Brody, Jennifer A.
Le, Phuong
Feitosa, Mary F.
Wojczynski, Mary K.
Hemerich, Daiane
Preuss, Michael
Mangino, Massimo
Christofidou, Paraskevi
Verweij, Niek
Benjamins, Jan W.
Engmann, Jorgen
Noah, Tsao L.
Verma, Anurag
Slieker, Roderick C.
Lo, Ken Sin
Zilhao, Nuno R.
Kleber, Marcus E.
Delgado, Graciela E.
Huo, Shaofeng
Ikeda, Daisuke D.
Iha, Hiroyuki
Yang, Jian
Liu, Jun
Demirkan, Ayse
Leonard, Hampton L.
Marten, Jonathan
Emmel, Carina
Schmidt, Borge
Smyth, Laura J.
Canadas-Garre, Marisa
Wang, Chaolong
Nakatochi, Masahiro
Wong, Andrew
Hutri-Kahonen, Nina
Sim, Xueling
Xia, Rui
Huerta-Chagoya, Alicia
Fernandez-Lopez, Juan Carlos
Lyssenko, Valeriya
Nongmaithem, Suraj S.
Sankareswaran, Alagu
Irvin, Marguerite R.
Oldmeadow, Christopher
Kim, Han-Na
Ryu, Seungho
Timmers, Paul R. H. J.
Arbeeva, Liubov
Dorajoo, Rajkumar
Lange, Leslie A.
Prasad, Gauri
Lores-Motta, Laura
Pauper, Marc
Long, Jirong
Li, Xiaohui
Theusch, Elizabeth
Takeuchi, Fumihiko
Spracklen, Cassandra N.
Loukola, Anu
Bollepalli, Sailalitha
Warner, Sophie C.
Wang, Ya Xing
Wei, Wen B.
Nutile, Teresa
Ruggiero, Daniela
Sung, Yun Ju
Chen, Shufeng
Liu, Fangchao
Yang, Jingyun
Kentistou, Katherine A.
Banas, Bernhard
Morgan, Anna
Meidtner, Karina
Bielak, Lawrence F.
Smith, Jennifer A.
Hebbar, Prashantha
Farmaki, Aliki-Eleni
Hofer, Edith
Lin, Maoxuan
Concas, Maria Pina
Vaccargiu, Simona
van der Most, Peter J.
Pitkanen, Niina
Cade, Brian E.
van der Laan, Sander W.
Chitrala, Kumaraswamy Naidu
Weiss, Stefan
Bentley, Amy R.
Doumatey, Ayo P.
Adeyemo, Adebowale A.
Lee, Jong Young
Petersen, Eva R. B.
Nielsen, Aneta A.
Choi, Hyeok Sun
Nethander, Maria
Freitag-Wolf, Sandra
Southam, Lorraine
Rayner, Nigel W.
Wang, Carol A.
Lin, Shih-Yi
Wang, Jun-Sing
Couture, Christian
Lyytikainen, Leo-Pekka
Nikus, Kjell
Cuellar-Partida, Gabriel
Vestergaard, Henrik
Hidalgo, Bertha
Giannakopoulou, Olga
Cai, Qiuyin
Obura, Morgan O.
van Setten, Jessica
He, Karen Y.
Tang, Hua
Terzikhan, Natalie
Shin, Jae Hun
Jackson, Rebecca D.
Reiner, Alexander P.
Martin, Lisa Warsinger
Chen, Zhengming
Li, Liming
Kawaguchi, Takahisa
Thiery, Joachim
Bis, Joshua C.
Launer, Lenore J.
Li, Huaixing
Nalls, Mike A.
Raitakari, Olli T.
Ichihara, Sahoko
Wild, Sarah H.
Nelson, Christopher P.
Campbell, Harry
Jager, Susanne
Nabika, Toru
Al-Mulla, Fahd
Niinikoski, Harri
Braund, Peter S.
Kolcic, Ivana
Kovacs, Peter
Giardoglou, Tota
Katsuya, Tomohiro
de Kleijn, Dominique
de Borst, Gert J.
Kim, Eung Kweon
Adams, Hieab H. H.
Ikram, M. Arfan
Zhu, Xiaofeng
Asselbergs, Folkert W.
Kraaijeveld, Adriaan O.
Beulens, Joline W. J.
Shu, Xiao-Ou
Rallidis, Loukianos S.
Pedersen, Oluf
Hansen, Torben
Mitchell, Paul
Hewitt, Alex W.
Kahonen, Mika
Perusse, Louis
Bouchard, Claude
Tonjes, Anke
Chen, Yii-Der Ida
Pennell, Craig E.
Mori, Trevor A.
Lieb, Wolfgang
Franke, Andre
Ohlsson, Claes
Mellstrom, Dan
Cho, Yoon Shin
Lee, Hyejin
Yuan, Jian-Min
Koh, Woon-Puay
Rhee, Sang Youl
Woo, Jeong-Taek
Heid, Iris M.
Stark, Klaus J.
Zimmermann, Martina E.
Volzke, Henry
Homuth, Georg
Evans, Michele K.
Zonderman, Alan B.
Polasek, Ozren
Pasterkamp, Gerard
Hoefer, Imo E.
Redline, Susan
Pahkala, Katja
Oldehinkel, Albertine J.
Snieder, Harold
Biino, Ginevra
Schmidt, Reinhold
Schmidt, Helena
Bandinelli, Stefania
Dedoussis, George
Thanaraj, Thangavel Alphonse
Peyser, Patricia A.
Kato, Norihiro
Schulze, Matthias B.
Girotto, Giorgia
Boger, Carsten A.
Jung, Bettina
Joshi, Peter K.
Bennett, David A.
De Jager, Philip L.
Lu, Xiangfeng
Mamakou, Vasiliki
Brown, Morris
Caulfield, Mark J.
Munroe, Patricia B.
Guo, Xiuqing
Ciullo, Marina
Jonas, Jost B.
Samani, Nilesh J.
Kaprio, Jaakko
Pajukanta, Paivi
Tusie-Luna, Teresa
Aguilar-Salinas, Carlos A.
Adair, Linda S.
Bechayda, Sonny Augustin
de Silva, H. Janaka
Wickremasinghe, Ananda R.
Krauss, Ronald M.
Wu, Jer-Yuarn
Zheng, Wei
den Hollander, Anneke, I
Bharadwaj, Dwaipayan
Correa, Adolfo
Wilson, James G.
Lind, Lars
Heng, Chew-Kiat
Nelson, Amanda E.
Golightly, Yvonne M.
Wilson, James F.
Penninx, Brenda
Kim, Hyung-Lae
Attia, John
Scott, Rodney J.
Rao, D. C.
Arnett, Donna K.
Walker, Mark
Scott, Laura J.
Koistinen, Heikki A.
Chandak, Giriraj R.
Mercader, Josep M.
Villalpando, Clicerio Gonzalez
Orozco, Lorena
Fornage, Myriam
Tai, E. Shyong
van Dam, Rob M.
Lehtimaki, Terho
Chaturvedi, Nish
Yokota, Mitsuhiro
Liu, Jianjun
Reilly, Dermot F.
McKnight, Amy Jayne
Kee, Frank
Jockel, Karl-Heinz
McCarthy, Mark, I
Palmer, Colin N. A.
Vitart, Veronique
Hayward, Caroline
Simonsick, Eleanor
van Duijn, Cornelia M.
Jin, Zi-Bing
Lu, Fan
Hishigaki, Haretsugu
Lin, Xu
Marz, Winfried
Gudnason, Vilmundur
Tardif, Jean-Claude
Lettre, Guillaume
Hart, Leen M. T.
Elders, Petra J. M.
Rader, Daniel J.
Damrauer, Scott M.
Kumari, Meena
Kivimaki, Mika
van der Harst, Pim
Spector, Tim D.
Loos, Ruth J. F.
Province, Michael A.
Parra, Esteban J.
Cruz, Miguel
Psaty, Bruce M.
Brandslund, Ivan
Pramstaller, Peter P.
Rotimi, Charles N.
Christensen, Kaare
Ripatti, Samuli
Widen, Elisabeth
Hakonarson, Hakon
Grant, Struan F. A.
Kiemeney, Lambertus
de Graaf, Jacqueline
Loeffler, Markus
Kronenberg, Florian
Gu, Dongfeng
Erdmann, Jeanette
Schunkert, Heribert
Franks, Paul W.
Linneberg, Allan
Jukema, J. Wouter
Khera, Amit, V
Mannikko, Minna
Jarvelin, Marjo-Riitta
Kutalik, Zoltan
Francesco, Cucca
Mook-Kanamori, Dennis O.
van Dijk, Ko Willems
Watkins, Hugh
Strachan, David P.
Grarup, Niels
Sever, Peter
Poulter, Neil
Sheu, Wayne Huey-Herng
Rotter, Jerome, I
Dantoft, Thomas M.
Karpe, Fredrik
Neville, Matt J.
Timpson, Nicholas J.
Cheng, Ching-Yu
Wong, Tien-Yin
Khor, Chiea Chuen
Li, Hengtong
Sabanayagam, Charumathi
Peters, Annette
Gieger, Christian
Hattersley, Andrew T.
Pedersen, Nancy L.
Magnusson, Patrik K. E.
Boomsma, Dorret, I
de Geus, Eco J. C.
Cupples, L. Adrienne
van Meurs, Joyce B. J.
Ikram, Arfan
Ghanbari, Mohsen
Gordon-Larsen, Penny
Huang, Wei
Kim, Young Jin
Tabara, Yasuharu
Wareham, Nicholas J.
Langenberg, Claudia
Zeggini, Eleftheria
Tuomilehto, Jaakko
Kuusisto, Johanna
Laakso, Markku
Ingelsson, Erik
Abecasis, Goncalo
Chambers, John C.
Kooner, Jaspal S.
de Vries, Paul S.
Morrison, Alanna C.
Hazelhurst, Scott
Ramsay, Michele
North, Kari E.
Daviglus, Martha
Kraft, Peter
Martin, Nicholas G.
Whitfield, John B.
Abbas, Shahid
Saleheen, Danish
Walters, Robin G.
Holmes, Michael, V
Black, Corri
Smith, Blair H.
Baras, Aris
Justice, Anne E.
Buring, Julie E.
Ridker, Paul M.
Chasman, Daniel, I
Kooperberg, Charles
Tamiya, Gen
Yamamoto, Masayuki
van Heel, David A.
Trembath, Richard C.
Wei, Wei-Qi
Jarvik, Gail P.
Namjou, Bahram
Hayes, M. Geoffrey
Ritchie, Marylyn D.
Jousilahti, Pekka
Salomaa, Veikko
Hveem, Kristian
Asvold, Bjorn Olav
Kubo, Michiaki
Kamatani, Yoichiro
Okada, Yukinori
Murakami, Yoshinori
Kim, Bong-Jo
Thorsteinsdottir, Unnur
Stefansson, Kari
Zhang, Jifeng
Chen, Y. Eugene
Ho, Yuk-Lam
Lynch, Julie A.
Tsao, Philip S.
Chang, Kyong-Mi
Cho, Kelly
O'Donnell, Christopher J.
Gaziano, John M.
Wilson, Peter
Mohlke, Karen L.
Frayling, Timothy M.
Hirschhorn, Joel N.
Kathiresan, Sekar
Boehnke, Michael
Grant, Struan
Natarajan, Pradeep
Sun, Yan, V
Morris, Andrew P.
Deloukas, Panos
Peloso, Gina
Assimes, Themistocles L.
Willer, Cristen J.
Zhu, Xiang
Brown, Christopher D.
AffiliationUniv Penn, Perelman Sch Med, Dept Genet, Philadelphia, PA 19104 USA
Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA
Univ Michigan, Dept Internal Med, Div Cardiol, Ann Arbor, MI 48109 USA
Queen Mary Univ London, John Vane Sci Ctr, Barts & London Sch Med & Dent, William Harvey Res Inst, Charterhouse Sq, London EC1M 6BQ, England
Boston Univ, Dept Biostat, Sch Publ Hlth, 801 Massachusetts Ave, Boston, MA 02118 USA
VA Palo Alto Hlth Care Syst, Palo Alto, CA 94304 USA
Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA
Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA USA
Boston Childrens Hosp, Endocrinol, Boston, MA 02115 USA
Broad Inst Harvard & MIT, Program Med & Populat Genet, 75 Ames St, Cambridge, MA 02142 USA
Univ Regensburg, Dept Genet Epidemiol, Regensburg, Germany
Washington Univ, McDonnell Genome Inst, St Louis, MO 63108 USA
Washington Univ, Dept Med, St Louis, MO 63108 USA
Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48109 USA
Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA
Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London EC1M 6BQ, England
Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA USA
Atlanta VA Hlth Care Syst, Decatur, GA USA
Malcolm Randall VA Med Ctr, Gainesville, FL USA
Univ Florida, Coll Med, Div Vasc Surg & Endovasc Therapy, Gainesville, FL USA
Amgen Inc, deCODE Genet, Sturlugata 8, IS-102 Reykjavik, Iceland
Univ Iceland, Sch Engn & Nat Sci, IS-102 Reykjavik, Iceland
Landspitali Natl Univ Hosp Iceland, Dept Clin Biochem, IS-101 Reykjavik, Iceland
Natl Inst Hlth, Dept Precis Med, Div Genome Sci, Chungbuk, South Korea
RIKEN Ctr Integrat Med Sci, Lab Stat Anal, Yokohama, Kanagawa, Japan
Kyushu Univ, Grad Sch Med Sci, Dept Ophthalmol, Fukuoka, Japan
Osaka Univ, Dept Stat Genet, Grad Sch Med, Osaka, Japan
Univ Tokyo, Lab Stat Anal, RIKEN Ctr Integrat Med Sci, Tokyo, Japan
Univ Tokyo, Grad Sch Med, Dept Allergy & Rheumatol, Tokyo, Japan
RIKEN Ctr Integrat Med Sci, Lab Stat & Translat Genet, Yokohama, Kanagawa, Japan
Harvard Med Sch, Dept Biomed Informat, Boston, MA 02115 USA
Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA
Norwegian Univ Sci & Technol, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Trondheim, Norway
Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit IEU, Oakfield House, Bristol BS8 2BN, Avon, England
Trondheim Reg & Univ Hosp, Clin Med, St Olavs Hosp, Trondheim, Norway
Univ Oslo, Div Med & Lab Sci, Oslo, Norway
Univ Helsinki, Inst Mol Med Finland FIMM, HiLIFE, Tukholmankatu 8, Helsinki 00014, Finland
Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland
Univ Penn, Perelman Sch Med, Inst Biomed Informat, Dept Genet, Philadelphia, PA 19104 USA
Northwestern Univ, Ctr Genet Med, Feinberg Sch Med, Chicago, IL 60611 USA
Univ Washington, Dept Med Med Genet, Seattle, WA 98195 USA
Cincinnati Childrens Hosp Med Ctr, Div Biomed Informat, Cincinnati, OH 45229 USA
Vanderbilt Univ Sch Med, Dept Med, Div Clin Pharmacol, Nashville, TN USA
Mayo Clin, Dept Cardiovasc Med, Rochester, MN USA
Mayo Clin, Gonda Vasc Ctr, Rochester, MN USA
Tohoku Univ, Tohoku Med Megabank Org, Sendai, Miyagi 9808573, Japan
Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London, England
Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA
Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA
Univ Edinburgh, Western Gen Hosp, Ctr Genom & Expt Med, Inst Genet & Canc, Edinburgh EH4 2XU, Midlothian, Scotland
Univ Edinburgh, Usher Inst, Nine Edinburgh Bioquarter,9 Little France Rd, Edinburgh EH16 4UX, Midlothian, Scotland
Univ Oxford, Clin Trial Serv Unit, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England
Univ Oxford, Epidemiol Studies Unit, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England
Univ Oxford, Med Res Council Populat Hlth Res Unit, Nuffield Dept Populat Hlth, Oxford OX3 7LF, England
Ctr Noncommunicable Dis, Karachi, SD, Pakistan
Faisalabad Inst Cardiol, Faislabad, Pakistan
Qatar Univ, Dept Populat Med, QU Hlth, Coll Med, Doha, Qatar
Univ Michigan, Survey Res Ctr, Inst Social Res, Ann Arbor, MI 48104 USA
Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Program Genet Epidemiol & Stat Genet, 677 Huntington Ave, Boston, MA 02115 USA
Univ North Carolina Chapel Hill, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA
Univ Witwatersrand, Fac Hlth Sci, Sydney Brenner Inst Mol Biosci, Johannesburg, South Africa
Univ Oxford, Wellcome Ctr Human Genet, Oxford OX3 7BN, England
Univ Texas Hlth Sci Ctr Houston, Human Genet Ctr, Sch Publ Hlth, Dept Epidemiol, Houston, TX 77030 USA
Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London W2 1PG, England
London North West Univ Healthcare NHS Trust, Ealing Hosp, Dept Cardiol, Harrow UB1 3HW, Middx, England
Imperial Coll London, Imperial Coll Healthcare NHS Trust, London W12 0HS, England
Uppsala Univ, Dept Med Sci, Mol Epidemiol & Sci Life Lab, Uppsala, Sweden
Univ Cambridge, MRC Epidemiol Unit, Sch Clin Med, Cambridge CB2 0QQ, England
Univ Cambridge, Dept Publ Hlth & Primary Care, Cardiovasc Epidemiol Unit, Strangeways Res Lab, Cambridge CB1 8RN, England
Kyoto Univ, Ctr Genom Med, Grad Sch Med, Kyoto, Japan
Univ Med Ctr Rotterdam, Dept Internal Med, Erasmus MC, Rotterdam, Netherlands
Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands
Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands
Univ Exeter, Univ Exeter Med Sch, Genet Complex Traits, Exeter EX2 5DW, Devon, England
Nanjing Univ Chinese Med, Dept Clin Acupuncture & Moxibust, Nanjing 210029, Jiangsu, Peoples R China
Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany
Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany
Univ Bristol, Bristol Dent Sch, Lower Maudlin St, Bristol BS1 2LY, Avon, England
Univ Bristol, Bristol Med Sch, Bristol BS8 2BN, Avon, England
Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117549, Singapore
Natl Univ Hlth Syst, Singapore 117549, Singapore
Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark
Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark
Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat,LABioMed, Torrance, CA 90502 USA
Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA 22903 USA
Taichung Vet Gen Hosp, Dept Med Res, 1650,Sec 4,Taiwan Blvd, Taichung 40705, Taiwan
Natl Hlth Res Inst, Inst Populat Hlth Sci, 35 Keyan Rd, Zhunan Town 350, Miaoli County, Taiwan
Queen Mary Univ London, NIHR Barts Cardiovasc Biomed Res Ctr, Barts & London Sch Med & Dent, London EC1M 6BQ, England
Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Copenhagen, Denmark
Univ Oxford, John Radcliffe Hosp, Radcliffe Dept Med, Div Cardiovasc Med, Oxford OX3 9DU, England
St Pau Biomed Res Inst IIB St Pau, Unit Genom Complex Dis, Barcelona, Spain
Karolinska Univ Hosp, Ctr Mol Med, Karolinska Inst, Dept Med,Cardiovasc Med Unit, Stockholm, Sweden
Leiden Univ Med Ctr, Dept Internal Med, Sect Gerontol & Geriatr, Leiden, Netherlands
CNR, Ist Ric Genet & Biomed, Rome, Italy
Univ Sassari, Dipartimento Sci Biomed, Sardinia, Italy
Univ Lausanne, Univ Ctr Primary Care & Publ Hlth, Rte Berne 113, CH-1010 Lausanne, Switzerland
Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland
Lausanne Univ Hosp, Dept Med, Internal Med, Rue Bugnon 46, CH-1011 Lausanne, Switzerland
Univ Lausanne, Rue Bugnon 46, CH-1011 Lausanne, Switzerland
Leiden Univ Med Ctr, Dept Cardiol, Leiden, Netherlands
BHF Glasgow Cardiovasc Res Ctr, Fac Med, Glasgow, Lanark, Scotland
Univ Lubeck, Inst Cardiogenet, DZHK German Res Ctr Cardiovasc Res, Univ Heart Ctr Lubeck,Partner Site Hamburg Lubeck, Lubeck, Germany
Charite Univ Med Berlin, Berlin, Germany
Free Univ Berlin, Berlin, Germany
Humboldt Univ, Berlin, Germany
Berlin Inst Hlth, Inst Dent & Craniofacial Sci, Dept Periodontol & Synopt Dent, Berlin, Germany
Tech Univ Munich, Deutsch Herzzentrum Munchen, Klin Herz & Kreislauferkrankungen, Munich, Germany
Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partner Site Munich Heart Alliance, Munich, Germany
Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Key Lab Cardiovasc Epidemiol,State Key Lab Cardio, Beijing 100037, Peoples R China
Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Epidemiol, Beijing 100037, Peoples R China
Lund Univ, Lund Univ Diabet Ctr, Malmo, Sweden
Med Univ Innsbruck, Inst Genet Epidemiol, Dept Genet & Pharmacol, Innsbruck, Austria
German Chron Kidney Dis Study, Innsbruck, Austria
Univ Leipzig, Inst Med Informat Stat & Epidemiol, Haertelstr 16-18, D-04107 Leipzig, Germany
Univ Leipzig, LIFE Res Ctr Civilizat Dis, Philipp Rosenthal Str 27, D-04103 Leipzig, Germany
Radboud Univ Nijmegen Med Ctr, Radboud Inst Hlth Sci, Nijmegen, Netherlands
Quantinuum Res LLC, Wayne, PA 19087 USA
Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63110 USA
Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15232 USA
Univ Lubeck, Inst Biomed, Eurac Res, Affiliated Inst, Via Galvani 31, I-39100 Bolzano, Italy
Lillebaelt Hosp, Dept Clin Biochem, Vejle, Denmark
Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA
Univ Toronto Mississauga, Dept Anthropol, Mississauga, ON L5L 1C6, Canada
Univ Toronto, Dept Comp Sci, Toronto, ON M5S 2E4, Canada
Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA
Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England
Guys & St Thomas Fdn Trust, NIHR Biomed Res Ctr, London SE1 9RT, England
Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, NL-9700 RB Groningen, Netherlands
UCL, Inst Cardiovasc Sci, Gower St, London WC1E 6BT, England
UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 6BT, England
Univ Penn, Dept Surg, Philadelphia, PA 19104 USA
Amsterdam UMC, Dept Epidemiol & Data Sci, Amsterdam Publ Hlth Res Inst, NL-1081 HV Amsterdam, Netherlands
Leiden Univ Med Ctr, Dept Cell & Chem Biol, NL-2333 ZA Leiden, Netherlands
Univ Montreal, Montreal Heart Inst, 5000 Belanger St, Montreal, PQ H1T 1C8, Canada
Iceland Heart Assoc, IS-201 Kopavogur, Iceland
Heidelberg Univ, Med Fac Mannheim, Dept Med 5, D-68163 Mannheim, Germany
MVZ Humangenet Mannheim GmbH, SYNLAB, D-68163 Mannheim, Germany
Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai, Peoples R China
Otsuka Pharmaceut Co Ltd, Tokushima Res Inst, Biomed Technol Res Ctr, Tokushima, Japan
Westlake Univ, Sch Life Sci, Hangzhou 310024, Zhejiang, Peoples R China
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Univ Western Australia, Med Sch, Discipline Internal Med, Perth, WA, Australia
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Sahlgrens Univ Hosp, Dept Drug Treatment, Gothenburg, Sweden
U
KeywordsINTEGRATIVE ANALYSIS
WIDE ASSOCIATION
3D GENOME
VARIANTS
CHOLESTEROL
ANNOTATION
OBESITY
COMMON
LOCI
EXPRESSION
Issue Date4-Aug-2022
PublisherAMERICAN JOURNAL OF HUMAN GENETICS
AbstractA major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expression quantitative trait locus (eQTL) colocalizations and then add chromatin interaction data to narrow the search for functional genes. Polygenic enrichment analysis across 697 annotations from a host of tissues and cell types confirms the central role of the liver in lipid levels and highlights the selective enrichment of adipose-specific chromatin marks in high-density lipoprotein cholesterol and triglycerides. Overlapping transcription factor (TF) binding sites with lipid-associated loci identifies TFs relevant in lipid biology. In addition, we present an integrative framework to prioritize causal variants at GWAS loci, producing a comprehensive list of candidate causal genes and variants with multiple layers of functional evidence. We highlight two of the prioritized genes, CREBRF and RRBP1, which show convergent evidence across functional datasets supporting their roles in lipid biology.
URIhttp://hdl.handle.net/20.500.11897/654291
ISSN0002-9297
DOI10.1016/j.ajhg.2022.06.012
IndexedSCI(E)
Appears in Collections:公共卫生学院

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