| Title | Bioactive abietane diterpenes and benzofuran neolignans from the resins of Toxicodendron vernicifluum |
| Authors | Liu, Qian Chen, Xu Wang, Shu-Hui Li, Chun Zhao, Ming-Bo Tu, Peng-Fei Jiang, Yong |
| Affiliation | Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China Beijing Univ Chinese Med, Coll Chinese Med, Beijing 100029, Peoples R China |
| Keywords | TANSHINONE IIA PROTECTS CARDIAC FIBROSIS INHIBITION URUSHIOLS LEAVES |
| Issue Date | Nov-2022 |
| Publisher | FITOTERAPIA |
| Abstract | Six new compounds (1-6), including two abietane diterpenes (1,2) and four benzofuran neolignans (3-6), along with five known compounds (7-11) were isolated and identified through phytochemical investigation on the resins of Toxicodendron vernicifluum (Toxicodendri Resina). The structures of the new compounds were fully elucidated by their 1D and 2D NMR, HRESIMS, UV, and IR spectroscopic data analyses. The absolute configu-rations of 1-4 were deduced by comparison of the experimental and calculated electronic circular dichroism (ECD) data. The inhibitory effects of the isolates on myocardial fibrosis induced by TGF-8 were examined, and compounds 1, 5, and 7-10 showed the anti-proliferation of myocardial fibroblasts at the concentrations of 10-40 mu M in a dose-dependent manner. |
| URI | http://hdl.handle.net/20.500.11897/657901 |
| ISSN | 0367-326X |
| DOI | 10.1016/j.fitote.2022.105332 |
| Indexed | SCI(E) |
| Appears in Collections: | 药学院 天然药物与仿生药物国家重点实验室 |
