TitleNegative emotion-conditioned prepulse induces the attentional enhancement of prepulse inhibition in humans
AuthorsYang, Xiaoqin
Chen, Liangjie
Yang, Pengcheng
Yang, Xiaodong
Liu, Lei
Li, Liang
AffiliationCapital Med Univ, Beijing Inst Brain Disorders, Collaborat Innovat Ctr Brain Disorders, Lab Brain Disorders,Minist Sci & Technol, Beijing 100069, Peoples R China
Peking Univ, Sch Psychol & Cognit Sci, Key Lab Machine Percept, Beijing Key Lab Behav & Mental Hlth,Minist Educ, Beijing 100080, Peoples R China
Peking Univ, Natl Inst Drug Dependence, Beijing, Peoples R China
Peking Univ, Beijing Key Lab Drug Dependence, Beijing, Peoples R China
KeywordsACOUSTIC STARTLE RESPONSE
SEX-DIFFERENCES
EYEBLINK MODIFICATION
MODULATED STARTLE
MENSTRUAL-CYCLE
REFLEX
HABITUATION
GENDER
FACILITATION
SPEECH
Issue Date13-Feb-2023
PublisherBEHAVIOURAL BRAIN RESEARCH
AbstractPrepulse inhibition (PPI) is a reduction of the acoustic startle reflex (ASR) when the startling stimulus is preceded by a weaker and non-startling stimulus (i.e., prepulse). Previous studies have revealed that PPI can be top-down modulated by selective attention to the fear-conditioned prepulse in animals. However, few researchers have tested this assumption in humans. Thus, in this study, the negative emotional-conditioned prepulse (CS+) was used to explore whether it could improve participants' attention, and further improve the PPI. The results showed that the CS+ prepulse increased the PPI only in females, PPI produced by CS+ prepulse was larger in females than in males, and the perceptual spatial attention further improved the PPI in both females and males. The results suggested that the PPI was affected by emotional, perceptual spatial attention, and sex. These findings highlight an additional method to measure top-down attentional regulation of PPI in humans. Which may offer a useful route to enhance the diagnosis of affective disorders, such as anxiety, depression, and post-traumatic stress disorder.
URIhttp://hdl.handle.net/20.500.11897/658253
ISSN0166-4328
DOI10.1016/j.bbr.2022.114179
IndexedSCI(E)
Appears in Collections:心理与认知科学学院
机器感知与智能教育部重点实验室
行为与心理健康北京市重点实验室
医学部待认领

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