TitleAge-specific random day serum antimullerian hormone reference values for women of reproductive age in the general population: a large Chinese nationwide population-based survey
AuthorsHao, Yongxiu
Yang, Rui
Li, Jia
Zhou, Zehong
Qian, Weiping
Zhang, Jian
Wu, Ze
Jin, Lei
Wu, Xueqing
Zhang, Cuilian
Zheng, Beihong
Tan, Jichun
Hao, Guimin
Li, Shangwei
Li, Qin
Zheng, Danni
Wang, Yuanyuan
Li, Rong
Liu, Ping
Qiao, Jie
AffiliationPeking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing, Peoples R China
Peking Univ Third Hosp, Natl Clin Res Ctr Obstet & Gynecol, Beijing, Peoples R China
Peking Univ, Minist Educ, Key Lab Assisted Reprod, Beijing, Peoples R China
Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing, Peoples R China
Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Guangzhou Inst Pediat, Guangzhou, Peoples R China
Guangzhou Med Univ, Dept Obstet & Gynecol, Guangzhou Women & Childrens Med Ctr, Guangzhou, Peoples R China
Peking Univ, Dept Reprod Med, Shenzhen Hosp, Shenzhen, Guangdong, Peoples R China
Shanghai Jiao Tong Univ, Sch Med, Chinese Minist Educ, Dept Pathophysiol,Key Lab Cell Differentiat & Apo, Shanghai, Peoples R China
First Peoples Hosp Yunnan Prov, Dept Reprod Med, Kunming, Yunnan, Peoples R China
Huazhong Univ Sci & Technol, Tongji Med Coll, Reprod Med Ctr, Tongji Hosp, Wuhan, Hubei, Peoples R China
Shanxi Med Univ, Reprod Med Ctr, Childrens Hosp Shanxi, Affiliate Hosp, Taiyuan, Shanxi, Peoples R China
Shanxi Med Univ, Women Hlth Ctr Shanxi, Affiliate Hosp, Taiyuan, Shanxi, Peoples R China
Henan Prov Peoples Hosp, Reprod Med Ctr, Zhengzhou, Henan, Peoples R China
Fujian Med Univ, Fujian Prov Matern & Childrens Hosp, Reprod Med Ctr, Affiliated Hosp, Fuzhou, Fujian, Peoples R China
China Med Univ, Ctr Reprod Med, Dept Obstet & Gynecol, Shengjing Hosp, Shenyang, Liaoning, Peoples R China
Hebei Med Univ, Dept Reprod Med, Hosp 2, Shijiazhuang, Hebei, Peoples R China
Sichuan Univ, Div Reprod Med Ctr, Dept Obstet & Gynecol, West China Univ Hosp 2, Chengdu, Sichuan, Peoples R China
KeywordsANTI-MULLERIAN HORMONE
OVARIAN RESERVE
INTERNATIONAL STANDARDS
REFERENCE RANGE
HEALTHY
STIMULATION
MARKERS
Issue DateDec-2022
PublisherAMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
AbstractBACKGROUND: Antimullerian hormone, the most reliable biomarker of ovarian reserve, is widely used in various clinical situations. Antimullerian hormone levels consistently decrease with age. However, there is no standard, age-specific reference values for antimullerian hormone in women of reproductive age, which limits its application. OBJECTIVE: This study aimed to establish age-specific antimullerian hormone percentile reference values for women of reproductive age. STUDY DESIGN: A nationwide, population-based cross-sectional survey was conducted between May 2019 and April 2021 in 15 provinces and municipalities in mainland China. A total of 10,053 eligible women aged 20 to 49 years were selected using a multistage stratified sampling procedure. Women who were pregnant, had undergone ovarian surgery, took hormone drugs in the past 3 months, or had an antimullerian hormone outlier value were excluded from establishing antimullerian hormone percentile reference values. Serum antimullerian hormone concentrations were measured using ultrasensitive, 2-site enzyme-linked immunosorbent assays (Ansh Lab, Webster, TX) in the Reproductive Endocrinology Laboratory of Peking University Third Hospital. Generalized additive models for location scale and shape with the Box-Cox t original distribution were used to estimate the fitted antimullerian hormone percentile reference values. RESULTS: A total of 9112 eligible women aged 21 to 49 years were included in the fitting model. The fitted 50th (2.5th-97.5th) percentiles of antimullerian hormone values for women aged 21, 25, 30, 35, 40, 45, and 49 years were 4.83 (0.79-18.41), 4.47 (0.72-16.58), 3.67 (0.50-13.82), 2.59 (0.24-10.35), 1.35 (0.05-6.68), 0.33 (<0.01 to 3.40), and 0.04 (<0.01 to 1.77) ng/mL, respectively. The populationbased decline rate of antimullerian hormone accelerated with increasing age, especially age >35 years. The magnitude of the decline of the 25th antimullerian hormone percentile curve was greater than that of the 75th percentile curve. CONCLUSION: This study established age-specific antimullerian hormone percentile reference values for women of reproductive age based on a large representative sample of the general population and described antimullerian hormone changes. These findings may facilitate antimullerian hormone application in clinical practices.
URIhttp://hdl.handle.net/20.500.11897/670140
ISSN0002-9378
DOI10.1016/j.ajog.2022.07.029
IndexedSCI(E)
Appears in Collections:第三医院
深圳医院

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